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acetyl- isoleucyl- glutamyl- threonyl- aspartyl- aldehyde

inhibits caspase-8; structure of complex in first source

Also Known As:

Ac-IETD-aldehyde; acetyl-Ile-Glu-Thr-Asp-aldehyde

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - acetyl-isoleucyl-glutamyl-threonyl-aspartyl-aldehyde: 1

Related Diseases

1.

10/01/1999 - "Inhibition of caspase activation by overexpression of a cowpox-derived caspase inhibitor CrmA or by addition of inhibitory peptides acetyl-Asp-Glu-Val-Asp-aldehyde (200 microM), acetyl-Ile-Glu-Thr-Asp-aldehyde (50 microM), and Z-Val-Ala-D,L-Asp-fluoromethylketone (1 microM) showed no effect on the induction of growth arrest or apoptosis by vitamin D compounds under assay conditions in which apoptosis induced by TNF or staurosporine was effectively inhibited. "

Related Drugs and Biologics

1.	Caspases
2.	Staurosporine
3.	Vitamin D
4.	Peptides (Polypeptides)
5.	Aldehydes
6.	aspartylglutamate