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R116301

Also Known As:

(2R-trans)-4-(1-(3,5- bis(trifluoromethyl)benzoyl)-2-(phenylmethyl)-4-piperidinyl)-N-(2,6-dimethylphenyl)-1-acetamide (S) hydroxybutanedioate; R 116301

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Malates
      - R116301: 1
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - Malates
        R116301: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - R116301: 1

Experts

1.	Ashton, D: 1 article (08/2002)
2.	Fransen, J F: 1 article (08/2002)
3.	Hens, K A: 1 article (08/2002)
4.	Heylen, L: 1 article (08/2002)
5.	Hillen, L C: 1 article (08/2002)
6.	Janssens, F: 1 article (08/2002)
7.	Jurzak, M R: 1 article (08/2002)
8.	Leysen, J E: 1 article (08/2002)
9.	Mahieu, M: 1 article (08/2002)
10.	Megens, A A H P: 1 article (08/2002)

Related Diseases

1.	Miosis 08/01/2002 - "R116301 did not affect senktide-induced miosis (>5 mg/kg, s.c.) in rabbits, confirming the absence of an interaction with the NK(3) receptor. "
2.	Cough 08/01/2002 - "R116301 inhibited the ocular discharge (0.034 mg/kg) but not the dyspnoea, lethality, or cough (>40 mg/kg, s.c.) induced by [betaALA(8)]-neurokinin A (NKA) (4-10) in guinea pigs, attesting to NK(1) over NK(2) selectivity. "

Related Drugs and Biologics

1.	Neurokinin-3 Receptors
2.	Neurokinin A
3.	senktide
4.	NK 2 (NK-2)