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N-(2,6-diethylphenyl)homophthalimide

structure in first source

Also Known As:

PIQ 22; PIQ-22

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - N-(2,6-diethylphenyl)homophthalimide: 2

Related Diseases

1.	Neoplasms (Cancer) 01/01/1999 - "PIQ-22 showed potent tumor-cell invasion-inhibitory activity." 09/01/1999 - "We show here that PIQ-22 and its 2,6-dimethylphenyl derivative (PIQ-11) are more potent inhibitors of tumor cell invasion than bestatin and actinonin in a Matrigel assay using mouse melanoma B16F10/L5 cells."
2.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 09/01/1999 - "Among them, N-(2,6-diethylphenyl)homophthalimide (PIQ-22) possesses a specific aminopeptidase-inhibiting activity more potent than that of bestatin or actinonin, as assayed in terms of hydrolysis of L-alanine 4-methylcoumaryl-7-amide (Ala-AMC) by human acute lymphoblastic leukemia MOLT-4 cells. "
3.	Melanoma (Melanoma, Malignant) 09/01/1999 - "We show here that PIQ-22 and its 2,6-dimethylphenyl derivative (PIQ-11) are more potent inhibitors of tumor cell invasion than bestatin and actinonin in a Matrigel assay using mouse melanoma B16F10/L5 cells."

Related Drugs and Biologics

1.	Aminopeptidases
2.	Alanine (L-Alanine)
3.	4-methyl-coumaryl-7-amide
4.	matrigel
5.	ubenimex
6.	actinonin