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recombinant methionyl human leptin

Also Known As:
r-MetHUleptin
Networked: 30 relevant articles (7 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Mantzoros, Christos S: 11 articles (01/2016 - 05/2003)
2. Chan, Jean L: 8 articles (02/2009 - 05/2003)
3. Gorden, Phillip: 7 articles (04/2008 - 02/2002)
4. DePaoli, Alex M: 6 articles (05/2005 - 02/2002)
5. Depaoli, Alex M: 5 articles (09/2007 - 07/2002)
6. Oral, Elif Arioglu: 4 articles (04/2005 - 02/2002)
7. Lee, Jennifer H: 3 articles (02/2009 - 06/2004)
8. Licinio, Julio: 3 articles (12/2008 - 05/2005)
9. Wong, Ma-Li: 3 articles (12/2008 - 05/2005)
10. Cochran, Elaine K: 3 articles (04/2008 - 04/2005)

Related Diseases

1. Insulin Resistance
2. Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy)
3. Weight Loss (Weight Reduction)
09/01/2007 - "To compliment the acute study, we retrospectively analyzed available BP results from a previously performed 85-day, placebo-controlled, randomized, double-blind, parallel weight-loss study using r-metHuLeptin in 284 obese adults. "
09/01/2007 - "In the retrospective analysis of the weight loss study data, 10 mg every day before noon (QAM), 10 mg every day after noon (QPM), or 10 mg twice a day (BID) SC of r-metHuLeptin was found to not alter the degree of weight loss (-3.2 +/- 3.7 versus -2.9 +/- 3.2 Kg, P = .54), change in systolic (-1.6 + 12.9 versus -2.0 +/- 13.9 mmHg, P = .85) and diastolic BP (-0.2 +/- 8.7 versus -1.5 +/- 8.6, P = .30), as well as heart rate (-1.4 +/- 10.7 versus -1.4 +/- 10.4 beats/min, P = .98) compared to placebo. "
10/01/2012 - "However, if r-metHuLeptin treatment has been shown to be dramatically efficient in leptin-deficient states, its very limited effect in inducing weight loss in common obese patients revealed that, in patients with adequate leptin secretion, mechanisms of leptin resistance and leptin tolerance prevent r-metHuLeptin from inducing any additional effects. "
08/29/2008 - "We concluded that replacement with r-metHuLeptin is associated with weight loss and changes in rates of development in many neurocognitive domains, which lends support to the hypothesis that, in addition to its role in metabolism, leptin may have a cognitive enhancing role in the developing central nervous system. "
01/01/2008 - "Within each group, the subjects lost approximately 3-4 kg of bodyweight after 3 days of fasting (all p < 0.0001), but the amount and time course of weight loss did not differ according to the dose of r-metHuLeptin administered or the circulating leptin concentrations achieved. "
4. Metabolic Diseases (Metabolic Disease)
5. Donohue Syndrome

Related Drugs and Biologics

1. Leptin
2. recombinant methionyl human leptin
3. Insulin (Novolin)
4. metreleptin
5. Lamin Type A (Lamin A)
6. HDL Lipoproteins
7. Insulin-Like Growth Factor Binding Proteins
8. P-30 composite resin (P 30)
9. Therapeutic Uses
10. Triglycerides (Triacylglycerol)

Related Therapies and Procedures

1. Therapeutics
2. Highly Active Antiretroviral Therapy (HAART)
3. Injections
4. Aftercare (After-Treatment)