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kalkitoxin

from marine cyanobacterium, Lyngbya majuscula

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gerwick, William H: 2 articles (02/2021 - 03/2015)
2.	Valeriote, Frederick A: 2 articles (01/2020 - 03/2015)
3.	Kim, Hyoungsu: 1 article (02/2021)
4.	Li, Liang: 1 article (02/2021)
5.	Shrestha, Saroj Kumar: 1 article (02/2021)
6.	Soh, Yunjo: 1 article (02/2021)
7.	Yang, Ming: 1 article (02/2021)
8.	Crich, David: 1 article (01/2020)
9.	Dhanju, Sandeep: 1 article (01/2020)
10.	Media, Joseph: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 03/20/2015 - "Subsequent studies revealed that kalkitoxin generated a delayed form of colon tumor cell cytotoxicity in 7-day clonogenic cell survival assays. " 03/20/2015 - "Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells." 03/20/2015 - "Further studies indicate that kalkitoxin targets tumor angiogenesis by blocking the induction of angiogenic factors (i.e., VEGF) in tumor cells." 01/07/2023 - "Kalkitoxin (KT), a lipopeptide toxin derived from the marine cyanobacterium Moorena producens (previously Lyngbya majuscula), has an anti-metastatic effect on cancer cells. "
2.	Breast Neoplasms (Breast Cancer) 01/07/2023 - "Kalkitoxin: A Potent Suppressor of Distant Breast Cancer Metastasis." 03/20/2015 - "Kalkitoxin potently and selectively inhibited hypoxia-induced activation of HIF-1 in T47D breast tumor cells (IC50 5.6 nM). "
3.	Neoplasm Metastasis (Metastasis) 01/07/2023 - "Kalkitoxin: A Potent Suppressor of Distant Breast Cancer Metastasis."
4.	Leukemia 01/01/2020 - "10-Aza-9-oxakalkitoxin displays potent and selective cytotoxicity (IC50 2.4 ng mL-1) comparable to that of kalkitoxin itself (IC50 3.2 ng mL-1) against the human hepato-carcinoma cell line HepG2 over both the human leukemia cell line CEM and the normal hematopoietic CFU-GM. "
5.	Inflammation (Inflammations) 02/25/2021 - "In this regard, we recently examined the in vivo impact of kalkitoxin (KT), a marine product obtained from the marine cyanobacterium Moorena producens (previously Lyngbya majuscula), on the macrophage colony-stimulating factor (M-CSF) and on the receptor activator of nuclear factor κB ligand (RANKL)-stimulated in vitro osteoclastogenesis and inflammation-mediated bone loss. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Lipopeptides
3.	Macrophage Colony-Stimulating Factor
4.	Ligands