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SB 265123

structure in first source

Also Known As:

SB-265123

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - SB 265123: 2
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - SB 265123: 2
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Acetates: 4994
      - SB 265123: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Aminopyridines: 77
      - SB 265123: 2

Related Diseases

1.	Osteoporosis 07/05/1999 - "A representative of this series, SB 265123 (4), has 100% oral bioavailability in rats, and is orally active in vivo in the ovariectomized rat model of osteoporosis." 11/01/1999 - ", in the ovariectomy-induced rat model of osteoporosis, SB 265123 prevents bone resorption in a dose-dependent fashion. " 11/01/1999 - "Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis."
2.	Bone Resorption 11/01/1999 - "The compound inhibits alpha(v)beta(3)-mediated cell adhesion with an IC(50) = 60 nM and more importantly, inhibits human osteoclast-mediated bone resorption in vitro with an IC(50) = 48 nM. In vivo, SB 265123 completely blocks bone resorption in a thyroparathyroidectomized rat model of acute bone resorption when dosed at 2.5 mg/kg/h by continuous i.v. infusion. " 11/01/1999 - ", in the ovariectomy-induced rat model of osteoporosis, SB 265123 prevents bone resorption in a dose-dependent fashion. "

Related Drugs and Biologics

1.	Peptidomimetics
2.	Integrin alphaVbeta3
3.	arginyl-glycyl-aspartic acid

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)