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pifithrin

a tetrahydrobenzothiazol; inhibitor of P53 that protects mice from the side effects of cancer therapy; structure in first source
Also Known As:
1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)- benzothiazolyl)ethanone hydrobromide; 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide (1:1); 2-(2-imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone; PFT alpha; ethanone, 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-, hydrobromide (1:1); pifithrin-alpha
Networked: 172 relevant articles (11 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Greig, Nigel H: 7 articles (01/2020 - 11/2002)
2. Hoffer, Barry J: 3 articles (01/2020 - 05/2009)
3. Wang, Jia-Yi: 3 articles (01/2020 - 12/2016)
4. Yang, Ling-Yu: 3 articles (01/2020 - 12/2016)
5. Luo, Yu: 3 articles (01/2018 - 05/2009)
6. Heijnen, Cobi J: 3 articles (01/2017 - 11/2015)
7. Kavelaars, Annemieke: 3 articles (01/2017 - 11/2015)
8. Dong, Zheng: 2 articles (01/2021 - 01/2017)
9. Wang, Jue: 2 articles (11/2020 - 01/2019)
10. Tweedie, David: 2 articles (01/2020 - 12/2016)

Related Diseases

1. Mitochondrial Diseases (Mitochondrial Disease)
2. Neoplasms (Cancer)
3. Stroke (Strokes)
4. Acute Kidney Injury (Acute Renal Failure)
01/15/2012 - "The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury."
02/01/2007 - "Targeting p21 via the selective p53 inhibitor pifithrin-alpha was able to prevent acute renal failure when administered immediately before ischemia. "
12/01/2022 - "Pifithrin-α ameliorates glycerol induced rhabdomyolysis and acute kidney injury by reducing p53 activation."
11/18/2023 - ": 3-MA: 3-methyladenine; ACTA2/α-SMA: actin alpha 2, smooth muscle, aorta; ACTB/β-actin: actin, beta; AKI: acute kidney injury; aa: amino acid; ATG/Atg: autophagy related; BUN: blood urea nitrogen; ChIP: chromatin immunoprecipitation; CKD: chronic kidney disease; CM: conditioned medium; COL1A1: collagen, type I, alpha 1; COL4A1: collagen, type IV, alpha 1; CQ: chloroquine; DBA: dolichos biflorus agglutinin; EGR1: early growth response 1; ELK1: ELK1, member of ETS oncogene family; FGF2: fibroblast growth factor 2; FN1: fibronectin 1; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; HAVCR1/KIM-1: hepatitis A virus cellular receptor 1; IP: immunoprecipitation; LIR: LC3-interacting region; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MAP2K/MEK: mitogen-activated protein kinase kinase; MAPK: mitogen-activated protein kinase; NFKB: nuclear factor kappa B; PB1: Phox and Bem1; PFT: pifithrin α; PPIB/cyclophilin B: peptidylprolyl isomerase B; RT-qPCR: real time-quantitative PCR; SQSTM1/p62: sequestosome 1; TGFB1/TGF-β1: transforming growth factor beta 1; VIM: vimentin."
5. Inflammation (Inflammations)

Related Drugs and Biologics

1. pifithrin
2. Cisplatin (Platino)
3. Antioxidants
4. Peptides (Polypeptides)
5. Melatonin
6. Cyclin-Dependent Kinase 2
7. Annexin A5
8. Tumor Suppressor Protein p53
9. Steroids
10. Phosphates (Orthophosphate)

Related Therapies and Procedures

1. Radiotherapy
2. Transplantation
3. Therapeutics
4. Drug Therapy (Chemotherapy)
5. Nanospheres