mindin

08/01/2012 - "In this study, we investigated the role of mindin in cardiac hypertrophy using littermate Mindin knockout (Mindin ( -/- )) and wild-type (WT) mice. "
10/01/2011 - "This study was aimed to identify the effect of mindin on cardiac hypertrophy and the underlying mechanisms. "
10/01/2011 - "To further investigate the role of mindin in cardiac hypertrophy, we used cultured neonatal rat cardiomyocytes with gain and loss of mindin function and cardiac-specific Mindin-overexpressing transgenic (TG) mice. "
10/01/2011 - "Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling."
10/01/2011 - "The present study demonstrates for the first time that mindin serves as a novel mediator that protects against cardiac hypertrophy and the transition to heart failure by blocking AKT/GSK3β and TGF-β1-Smad signalling."

01/01/2020 - "Our study evidences that MINDIN secretion by primary prostate tumors creates a favorable bone environment for tumor cell homing before metastatic spread."
01/24/2021 - "MINDIN-dependent downregulation of NHERF-1 promoted tumor cell migration and proliferation without affecting osteomimicry and adhesion. "
01/01/2018 - "Overexpression of mindin suppressed xenograft tumor growth by blocking angiogenesis instead of directly suppressing CRC cell proliferation. "
09/15/2005 - "Gene expression analysis showed that a human mindin homologue, mindin/RG-1, is expressed selectively in prostate tissues and that its expression level is elevated in some prostate tumors. "
01/01/2022 - "Interestingly, disruption of this signaling module in human cSCC attenuates tumorigenesis, suggesting that targeting Mindin would be a promising therapeutic approach to hinder cancer recurrence."

12/01/2018 - "In contrary to previous studies, increased mindin levels may be associated with myocardial fibrosis."
01/01/2020 - "However, the role of mindin in renal fibrosis remains obscure. "
01/01/2020 - "Mindin deficiency alleviates renal fibrosis through inhibiting NF-κB and TGF-β/Smad pathways."
11/01/2017 - "Erratum to: Disruption of mindin exacerbates cardiac hypertrophy and fibrosis."
08/01/2012 - "Mindin ( -/- ) mice were more susceptible to cardiac hypertrophy and fibrosis in response to AB or Ang II stimulation than wild type. "

01/10/2020 - "The aim of the presented study was to investigate the serum mindin levels in prostate cancer. "
01/24/2021 - "We propose that MINDIN downregulates NHERF-1 expression leading to promotion of processes involved in prostate cancer progression."
01/24/2021 - "Upregulation of MINDIN and downregulation of NHERF-1 expression were observed both in human prostate cancer samples and in the TRAMP-C1 model. "
01/24/2021 - "We hypothesize that NHERF-1 modulation is a mechanism used by MINDIN to promote prostate cancer progression. "
01/10/2020 - "Mindin appears to be a promising diagnostic marker useful in the diagnosis of prostate cancer. "

05/01/2008 - "In this study, we examined the role of mindin in influenza virus infection. "
01/01/2023 - "Shrimp Mindin facilitates white spot syndrome virus infection by facilitating viral entry and replication. "
05/01/2008 - "We showed that mindin interacted with influenza virus particles directly and that mindin-deficient macrophages exhibited impaired activation after influenza virus infection in vitro. "
05/01/2008 - "We found that intranasal infection of mindin-deficient mice by influenza virus resulted in dramatically increased virus titers in the lung and intranasal cavity of mutant mice. "
05/01/2008 - "Together, these results demonstrate that mindin plays an essential role in the host innate immune response to influenza virus infection and suggest that mindin may be used as an immune-enhancing agent in influenza infection."