CD44V3,8-10

a cell adhesion receptor that binds extracellular matrix components at its extracellular domain

Also Known As:

CD44V3 antigen

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Proteoglycans: 4798
    - Chondroitin Sulfate Proteoglycans: 569
      - Hyaluronan Receptors: 308
        CD44V3,8-10: 5
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Proteoglycans: 4798
      - Chondroitin Sulfate Proteoglycans: 569
        Hyaluronan Receptors: 308
        CD44V3,8-10: 5
    - Membrane Glycoproteins: 2252
      - Cell Adhesion Molecules: 4858
        Lymphocyte Homing Receptors: 25
        Hyaluronan Receptors: 308
        CD44V3,8-10: 5
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Proteoglycans: 4798
      - Chondroitin Sulfate Proteoglycans: 569
        Hyaluronan Receptors: 308
        CD44V3,8-10: 5
    - Membrane Glycoproteins: 2252
      - Cell Adhesion Molecules: 4858
        Lymphocyte Homing Receptors: 25
        Hyaluronan Receptors: 308
        CD44V3,8-10: 5
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Cell Adhesion Molecules: 4858
        Lymphocyte Homing Receptors: 25
        Hyaluronan Receptors: 308
        CD44V3,8-10: 5
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Lymphocyte Homing Receptors: 25
        Hyaluronan Receptors: 308
        CD44V3,8-10: 5
Biological Factors: 2472
- Antigens: 143924
  - Surface Antigens: 5813
    - Cell Adhesion Molecules: 4858
      - Lymphocyte Homing Receptors: 25
        Hyaluronan Receptors: 308
        CD44V3,8-10: 5

Experts

1.	Edahiro, Keitaro: 1 article (08/2022)
2.	Fujimoto, Yoshiaki: 1 article (08/2022)
3.	Iimori, Makoto: 1 article (08/2022)
4.	Kitao, Hiroyuki: 1 article (08/2022)
5.	Maehara, Yoshihiko: 1 article (08/2022)
6.	Matsuoka, Kazuaki: 1 article (08/2022)
7.	Mori, Masaki: 1 article (08/2022)
8.	Oki, Eiji: 1 article (08/2022)
9.	Qiu, Shichao: 1 article (08/2022)
10.	Brandys, Anna: 1 article (01/2003)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2022 - "CD44v3,8-10 is essential for Slug-dependent vimentin gene expression to acquire TGF-β1-induced tumor cell motility." 01/01/2003 - "The presence of CD44v3 antigen on the surface of breast cancer cells significantly correlated with ER expression (0.0430) and the lack of p53 protein (p=0.0252), and also with the percentage of T cells in the total population of lymphocytes infiltrating the primary tumor (TILs) (p=0.0248). " 07/01/1998 - "These findings suggest that CD44v3,8-10 plays an important role in linking ankyrin to the membrane-associated actomyosin contractile system required for "invadopodia" formation (coupled with matrix degradation activities) and tumor cell migration during breast cancer progression." 08/01/2022 - "Among multiple CD44v isoforms expressed in NUGC3 gastric cancer cells, CD44v8-10 and CD44v3,8-10 are involved in the acquisition of migratory and invasive properties associated with TGF-β1-induced EMT, and only CD44v3,8-10 induces the transcription of vimentin mediated by the EMT transcription factor Slug. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2003 - "The presence of CD44v3 antigen on the surface of breast cancer cells significantly correlated with ER expression (0.0430) and the lack of p53 protein (p=0.0252), and also with the percentage of T cells in the total population of lymphocytes infiltrating the primary tumor (TILs) (p=0.0248). " 07/01/1998 - "These findings suggest that CD44v3,8-10 plays an important role in linking ankyrin to the membrane-associated actomyosin contractile system required for "invadopodia" formation (coupled with matrix degradation activities) and tumor cell migration during breast cancer progression." 01/01/1999 - "Using reverse transcriptase-polymerase chain reaction (RT-PCR) followed by Southern blot, cloning, nucleotide sequencing and RT-in situ-PCR analyses, we have found that at least two CD44v3-containing isoforms, including one new species of CD44v2,deltav3-10 (deltav3 defined as a v3 exon lacking the first 24 base pairs) and another previously reported CD44v3,8-10 are preferentially expressed in human primary breast tumor and axillary nodal metastases but not in normal breast tissues. "
3.	Neoplasm Metastasis (Metastasis) 01/01/1999 - "Using reverse transcriptase-polymerase chain reaction (RT-PCR) followed by Southern blot, cloning, nucleotide sequencing and RT-in situ-PCR analyses, we have found that at least two CD44v3-containing isoforms, including one new species of CD44v2,deltav3-10 (deltav3 defined as a v3 exon lacking the first 24 base pairs) and another previously reported CD44v3,8-10 are preferentially expressed in human primary breast tumor and axillary nodal metastases but not in normal breast tissues. "
4.	Lymphoma (Lymphomas) 02/01/1995 - "Finally we present evidence using transfected B lymphoma cells that the GAG-modified CD44 isoforms CD44v3-10 and CD44v3,8-10, unlike CD44H, bind only weakly to hyaluronan. "

Related Drugs and Biologics

1.	Protein Isoforms (Isoforms)
2.	Ankyrins
3.	Vimentin
4.	Transcription Factors (Transcription Factor)
5.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
6.	Proteins (Proteins, Gene)
7.	Nucleotides
8.	Hyaluronic Acid (Hyaluronan)
9.	Actomyosin