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4,5-dibromorhodamine 123

a low toxic photosensitizing agent

Also Known As:

TH 9402; TH9402

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - Rhodamines: 466
        4,5-dibromorhodamine 123: 2

Experts

1.	Brasseur, N: 1 article (12/2000)
2.	Forget, A: 1 article (12/2000)
3.	Hamel, R: 1 article (12/2000)
4.	Molfino, N A: 1 article (12/2000)
5.	Ménard, I: 1 article (12/2000)
6.	el Jastimi, R: 1 article (12/2000)
7.	van Lier, J E: 1 article (12/2000)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/1999 - "TH9402 photodynamic-cell-therapy process conditions recognized as safe for normal human haematopoietic stem cells and progenitors demonstrated the efficacy of the purging procedure on various leukaemias (including chronic-myelogenous-leukaemia as well as non-Hodgkin-leukaemias and metastatic-breast-cancer cell lines."
2.	Multiple Myeloma 12/01/2000 - "The aim of this study was to evaluate the potential of the photosensitizer 4,5-dibromorhodamine methyl ester (TH9402), a dibrominated rhodamine derivative, to eradicate multiple myeloma (MM) and BC cell lines, while sparing more than 50% of normal pluripotential blood stem cells from healthy volunteers. "
3.	Neoplasms (Cancer) 12/01/2000 - "The absence of significant toxicity towards normal hematopoietic stem cells, combined with the 5 logs eradication of cancer cell lines induced by this procedure suggests that TH9402 offers an excellent potential as an ex vivo photodynamic purging agent for autologous transplantation in MM and BC treatment."

Related Drugs and Biologics

1.	Photosensitizing Agents (Photosensitizers)
2.	Rhodamines
3.	4,5-dibromorhodamine methyl ester

Related Therapies and Procedures

1.	Cell- and Tissue-Based Therapy (Cell Therapy)
2.	Autologous Transplantation