tenecteplase

01/01/2001 - "Tenecteplase: a review of its pharmacology and therapeutic efficacy in patients with acute myocardial infarction."
05/01/2003 - "Safety and efficacy of tenecteplase in acute myocardial infarction."
06/01/2015 - "Reduced dose tenecteplase and outcomes in elderly ST-segment elevation myocardial infarction patients: Insights from the STrategic Reperfusion Early After Myocardial infarction trial."
01/01/2011 - "This study confirms the efficacy and safety of indigenous tenecteplase in the management of patients with ST-elevation myocardial infarction."
01/01/2011 - "To study the efficacy and safety of single intravenous bolus administration of indigenously developed tenecteplase in the management of patients presenting with ST-elevation myocardial infarction in clinical practice. "

10/01/2015 - "In patients with acute ischemic stroke, tenecteplase has shown promise in randomized phase II trials and the drug is currently being tested in four phase III clinical trials that will start delivering definite results in the near future: NOR-TEST (NCT01949948), TASTE (ACTRN12613000243718), TEMPO-2 (NCT02398656), and TALISMAN (NCT02180204). "
06/01/2014 - "Over the past few years, several clinical studies have been conducted to assess the safety, feasibility, and efficacy of tenecteplase in ischemic stroke. "
04/01/2015 - "Evaluation of tenecteplase in larger trials of patients with acute stroke seems warranted. "
04/01/2015 - "The newer thrombolytic drug tenecteplase has been investigated in one randomised trial up to 3 h after stroke and in another trial up to 6 h after stroke in patients selected by advanced neuroimaging. "
07/01/2012 - "We review the evidence for thrombolysis, experience with tenecteplase and compare this study with others that have used similar designs for the investigation of novel stroke lytic agents."

10/01/2012 - "We report a case of bilateral pulmonary thromboembolism with right heart thrombi treated successfully with thrombolysis with tenecteplase."
05/01/2011 - "The present study suggests favourable efficacy of tenecteplase in patients with suspected or confirmed acute pulmonary embolism. "
04/01/2007 - "Taken together, we submit that the present case report and prior case reports are sufficient to comprise a phase I study of the safety and efficacy of tenecteplase to treat acute pulmonary embolism."
04/01/2014 - "Treatment of submassive pulmonary embolism with tenecteplase or placebo: cardiopulmonary outcomes at 3 months: multicenter double-blind, placebo-controlled randomized trial."
01/01/2015 - "An unusual presentation of a massive pulmonary embolism with misleading investigation results treated with tenecteplase."

07/01/2014 - "Our study shows that tenecteplase is very effective and safe in the treatment of PE with minimal risk of bleeding in high risk group and intermediate risk and even in selective low risk category group of patients. "
01/01/2001 - "The apparent advantages of tenecteplase (reduced mortality in patients receiving late treatment and reduced incidence of noncerebral bleeding complications) in ASSENT-2 are of interest and merit further attention. "
04/10/2014 - "Extracranial bleeding occurred in 32 patients (6.3%) in the tenecteplase group and 6 patients (1.2%) in the placebo group (P<0.001). "
01/01/2013 - "Compared to other tPAs, tenecteplase use leads to lower rates of bleeding complications. "
01/01/2012 - "The purpose of this report was to describe a case with a thick submacular hemorrhage (SMH) resulting from polypoidal choroidal vasculopathy that was successfully treated with a subretinal tenecteplase injection. "

11/01/2005 - "In this study, the safety and efficacy of intracoronary tenecteplase (TNK) was evaluated in 34 patients (22 with acute ST elevation MI, 4 with rescue PCI, 6 with non-ST elevation MI, and 2 during elective PCI) who developed no-reflow, distal embolization, or visible intracoronary thrombus during PCI. "
12/01/2015 - "We hereby present a case of the use of Tenecteplase for recurrence of mitral valve thrombosis in a patient who was brought as an emergency with breathing difficulty at rest. "
12/01/2015 - "Tenecteplase can be a more effective and convenient alternative in treatment of prosthetic valve thrombosis (PVT). "
12/01/2015 - "Successful use of Tenecteplase in a patient with recurrence of prosthetic mitral valve thrombosis."
03/01/2014 - "Successful treatment of aortic prosthetic valve thrombosis with bolus dose Tenecteplase."