NR2B NMDA receptor

a N-Methyl-D-Aspartate receptor

Also Known As:

GLUN2B receptor; GRIN2B protein, human; GRIN2B receptor; Glurepsilon2; Grin2b protein, mouse; Grin2b protein, rat; NMDA receptor 2B; NMDAR2B protein, human; NR2B N-Methyl-D-Aspartate receptor; NR2B protein, rat; Nmda2b protein, rat; Nmdar2b protein, mouse; glutamate receptor epsilon 2 subunit; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, human; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, rat; glutamate receptor, ionotropic, NMDA2B (epsilon 2) protein, mouse; receptor 2B, NMDA

Networked: 47 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Takahashi, Yukitoshi: 10 articles (08/2010 - 08/2003)
2.	Gu, Xiaoping: 3 articles (11/2013 - 12/2009)
3.	Ma, Zhengliang: 3 articles (11/2013 - 12/2009)
4.	Fujiwara, Tateki: 3 articles (11/2008 - 01/2005)
5.	Kubota, Yuko: 3 articles (03/2008 - 01/2005)
6.	Hu, Xiao-Dong: 2 articles (03/2015 - 02/2014)
7.	Li, Lu: 2 articles (03/2015 - 02/2014)
8.	Suo, Zhan-Wei: 2 articles (03/2015 - 02/2014)
9.	Yang, Xian: 2 articles (03/2015 - 02/2014)
10.	Liu, Yue: 2 articles (07/2012 - 12/2009)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2007 - "Association study between the NMDA receptor 2B subunit gene (GRIN2B) and schizophrenia: a HuGE review and meta-analysis." 01/01/2017 - "Accordingly, we found that upon crack inhalation mice have shown decreased social interaction and working memory deficits analogous to schizophrenia's symptoms, along with increased D2S/D2L expression ratio and decreased expression of NR1, NR2A and NR2B NMDA receptor subunits in the PFC. " 07/01/2010 - "To analyze whether early events in NR2B processing are affected in schizophrenia, we have isolated a subcellular endoplasmic reticulum (ER)-enriched fraction from postmortem brain and analyzed expression of the NR1 and NR2B NMDA receptor subunits as well as PSD-95 in two areas of prefrontal cortex. " 08/01/2000 - "Novel polymorphism in the gene region encoding the carboxyl-terminal intracellular domain of the NMDA receptor 2B subunit: analysis of association with schizophrenia." 08/01/2006 - "We observed increased protein expression of the NR2B NMDA receptor subunit and its associated intracellular protein, PSD95, in the dorsomedial thalamus of patients with schizophrenia, but the other molecules were unchanged, and we found no changes in the ventral thalamus. "
2.	Hyperalgesia 10/13/2004 - "Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia." 12/30/2009 - "In the present study, we used a rat model of postoperative pain to investigate the role of tyrosine phosphorylation of NMDA receptor 2B (NR2B) subunit in spinal cord in the postoperative hyperalgesia induced by remifentanil and the intervention of pretreatment with ketamine. " 01/01/2020 - "Blocking NOX2 with blocking peptide or shRNA prevented the development of bilateral mechanical allodynia, the induction of spinal LTP, and the phosphorylation of N-methyl-d-aspartate (NMDA) receptor 2B (GluN2B) and nuclear factor kappa-B (NF-κB) p65 after HFS. " 01/01/2013 - "Our results demonstrate that the thermal hyperalgesia induced by intrathecal administration of NMDA is associated with spinal nitration of GluN1 and GluN2B receptor subunits, GS, that normally convert glutamate into nontoxic glutamine, and glutamate transporter GLT1. "
3.	Seizures (Absence Seizure) 01/01/2023 - "This study suggests that GP and ASP have a protective effect on PILO-induced seizures, decreasing GluN2B receptor and COX-2 expression." 01/01/2023 - "Geniposide and asperuloside alter the COX-2 and GluN2B receptor expression after pilocarpine-induced seizures in mice."
4.	Postoperative Pain 12/30/2009 - "In the present study, we used a rat model of postoperative pain to investigate the role of tyrosine phosphorylation of NMDA receptor 2B (NR2B) subunit in spinal cord in the postoperative hyperalgesia induced by remifentanil and the intervention of pretreatment with ketamine. "
5.	Pain (Aches) 10/16/2021 - "Inhibition of Spinal TRPV1 Reduces NMDA Receptor 2B Phosphorylation and Produces Anti-Nociceptive Effects in Mice with Inflammatory Pain." 02/01/2014 - "These data suggested that the noradrenergic suppression of inflammatory pain might involve the blockade of GluN2B receptor-mediated nociceptive transmission in spinal dorsal horn." 11/01/2013 - "NR2B subunits (NMDA receptor 2B subunit) play an important role in generation of pain and forming central sensitization of pain. " 01/15/2008 - "Switch to Ca2+-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat." 11/01/2023 - "Moreover, it was found that Calhm2 regulates inflammation pain promoting the upregulation of N-methyl-D-aspartic acid (NMDA) receptor 2B (NR2B) subunits. "

Related Drugs and Biologics

1.	Tyrosine (L-Tyrosine)
2.	Ketamine
3.	Remifentanil (Ultiva)
4.	N-Methylaspartate (NMDA)
5.	Autoantibodies
6.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
7.	Glutamate Receptors (Glutamate Receptor)
8.	Cytokines
9.	Antibodies
10.	Roscovitine