erythrocyte membrane protein band 4.1-like 1

46% identical to the erythrocyte membrane cytoskeletal protein 4.1 (4.1R); RefSeq NM_001003815 (mouse); NM_012156 (human)

Also Known As:

4.1N protein; EPB41L1; EPB41L1 protein, human; Epb4.1l1 protein, mouse; Epb41l1 protein, mouse; erythrocyte membrane protein band 4.1-like 1, human; erythrocyte protein band 4.1-like 1, mouse; neuronal membrane cytoskeletal protein 4.1; neuronal membrane cytoskeletal protein 4.1, mouse; protein 4.1N, mouse

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
- Peptides: 82426
  - Neuropeptides: 6772
    - erythrocyte membrane protein band 4.1-like 1: 6

Experts

1.	Li, Hui: 2 articles (01/2022 - 10/2019)
2.	Liu, Jing: 1 article (01/2022)
3.	Yang, Qin: 1 article (01/2022)
4.	Ye, Mao: 1 article (01/2022)
5.	Zhan, Peihe: 1 article (01/2022)
6.	Zhang, Bin: 1 article (01/2022)
7.	Zhu, Lin: 1 article (01/2022)
8.	Zou, Wen: 1 article (01/2022)
9.	Chen, Chen: 1 article (01/2020)
10.	Deng, Zhichao: 1 article (01/2020)

Related Diseases

1.	Carcinogenesis 12/01/2013 - "In this study, we evaluated the expression of 4.1N protein and its potential roles in epithelial ovarian cancer (EOC) tumorigenesis and progression. "
2.	Glioblastoma (Glioblastoma Multiforme) 10/01/2019 - "This study aims to confirm that miR-431-5p could influence the proliferation, invasion and migration of human glioblastoma multiforme cells by targeting EPB41L1 (erythrocyte membrane protein band 4.1). "
3.	Ovarian Epithelial Carcinoma 12/01/2013 - "In this study, we evaluated the expression of 4.1N protein and its potential roles in epithelial ovarian cancer (EOC) tumorigenesis and progression. "
4.	Neoplasms (Cancer) 01/01/2022 - "We previously identified that 4.1N/EPB41L1 acts as a tumor suppressor and is reduced in NSCLC patients. " 01/01/2022 - "Tumor Suppressor 4.1N/EPB41L1 is Epigenetic Silenced by Promoter Methylation and MiR-454-3p in NSCLC." 12/01/2013 - "4.1N protein expression level was significantly decreased during malignant transformation of epithelial ovarian tumors and that loss of 4.1N expression was closely correlated to poorly differentiated and biologically aggressive EOCs." 12/01/2013 - "Furthermore, loss or decreased expression of 4.1N protein expression was correlated with malignant potential of the tumors (14.3% in benign tumors, 56.7% in borderline tumors and 92.9% in malignancy) (p<0.001). " 12/01/2013 - "4.1N protein expression was investigated in a total of 280 samples including 74 normal tissues, 35 benign, 30 borderline and 141 malignant epithelial ovarian tumors by immunohistochemistry. "
5.	Neoplasm Metastasis (Metastasis) 01/01/2020 - "Further analysis suggested that EPB41L1 and amyloid beta precursor protein (APP) were coordinated to regulated cancer cell adhesion, thereby increasing the incidence of cancer cell metastasis and tumor invasion. " 12/01/2013 - "In EOC samples, loss of 4.1N protein was significantly associated with advanced-stage (p=0.004), ascites (p=0.009), omental metastasis (p=0.018), suboptimal debulking (p=0.024), poorly histological differentiation (p=0.009), high-grade serous carcinoma (p=0.001), short progression-free-survival (p=0.018) and poor chemosensitivity to first-line chemotherapy (p=0.029). "

Related Drugs and Biologics

1.	erythrocyte membrane band 4.1 protein (erythrocyte membrane band 4.1)
2.	Proteins (Proteins, Gene)
3.	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)
4.	ezrin

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)