separase

caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase; RefSeq NM_012291 (human); GenBank L07289 (S. cerevisiae)

Also Known As:

Networked: 28 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Pati, Debananda: 5 articles (08/2014 - 09/2008)
2.	Zhang, Nenggang: 5 articles (08/2014 - 09/2008)
3.	Hofmann, Wolf-Karsten: 3 articles (01/2015 - 01/2012)
4.	Seifarth, Wolfgang: 3 articles (01/2015 - 01/2012)
5.	Fabarius, Alice: 3 articles (01/2015 - 01/2012)
6.	Haaß, Wiltrud: 3 articles (01/2015 - 01/2012)
7.	Zhang, Pumin: 3 articles (01/2014 - 01/2008)
8.	Huang, Xingxu: 3 articles (01/2011 - 01/2008)
9.	Müller, Martin C: 2 articles (01/2015 - 01/2015)
10.	Kleiner, Helga: 2 articles (01/2015 - 01/2015)

Related Diseases

1.	Neoplasms (Cancer) 04/15/2009 - "In the present study, we have investigated the expression level of Separase across a wide range of human tumors. " 01/01/2007 - "Carcinogenesis studies demonstrated that cds heterozygous adults have a shift in tumor spectrum with an eightfold increase in the percentage of fish bearing epithelial tumors, indicating that separase is a tumor suppressor gene in vertebrates. " 11/27/2014 - "Separase protein and transcripts are overexpressed in a wide range of human cancers. " 08/01/2014 - "These results further strengthen our hypothesis that Separase is an oncogene whose overexpression induces tumorigenesis, and indicate that Separase overexpression and aberrant nuclear localization are common in many tumor types and may predict outcome in some human malignancies. " 08/01/2014 - "Tumor status and patient survival strongly correlate with the mislocalization of Separase into the nucleus throughout all stages of the cell cycle. "
2.	Genomic Instability 09/01/2009 - "Our study identifies SKAP as a novel regulator of the metaphase-to-anaphase transition and demonstrates that misregulation of the separase activation results in a reduced fidelity of chromosome segregation and a reduced genomic stability independent of the SAC." 01/01/2012 - "Activation of Separase proteolytic activity exclusively in p210BCR-ABL-positive cells during IM treatment may act as a driving force for centrosomal amplification, contributing to genomic instability, clonal evolution and resistance in CML." 01/01/2011 - "Our results reveal that Separase phospho-regulation is critical for genome stability in oogenesis. " 01/01/2011 - "We showed that Separase deregulation leads to chromosome mis-segregation, genome instability, and eventually apoptosis of primordial germ cells (PGCs) during embryonic oogenesis. " 01/01/2011 - "Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis."
3.	Aneuploidy (Aneuploid) 08/01/2014 - "Overexpression of Separase in animal models results in aneuploidy and tumorigenesis. " 01/01/2011 - "Homozygous deletion of ESPL1 gene that encodes Separase protein results in embryonic lethality in mice and Separase overexpression lead to aneuploidy and tumorigenesis. " 01/01/2011 - "Furthermore, we provided the first evidence of a pre-zygotic mitotic chromosome segregation error resulting from Separase deregulation, whose sex-specific differences may be a reason for the sexual dimorphism of aneuploidy in gametogenesis." 09/15/2009 - "Overexpression of separase induces aneuploidy and mammary tumorigenesis in mice. " 09/02/2008 - "These results collectively suggest that Separase is an oncogene, whose overexpression alone in mammary epithelial cells is sufficient to induce aneuploidy and tumorigenesis in a p53 mutant background."
4.	Polyploidy 03/13/2006 - "Thus, fibroblasts lacking Separase become highly polyploid. " 03/13/2006 - "Separase-deficient mouse embryonic fibroblasts exhibited severely restrained increases in cell number, polyploid chromosomes, and amplified centrosomes. " 08/20/2002 - "Inhibition of separase expression in human cells by RNA interference causes the formation of polyploid cells with large lobed nuclei. " 03/13/2006 - "Hepatocytes stimulated to proliferate in vivo by hepatectomy also become unusually large and polyploid in the absence of Separase but are able to regenerate functional livers. "
5.	Neoplasm Metastasis (Metastasis) 04/15/2009 - "Additionally, overexpression of Separase transcript strongly correlates with high incidence of relapse, metastasis, and lower 5-year overall survival rate in breast and prostate cancer patients. " 01/01/2013 - "The amount of Securin is strongly regulated because it should allow Separase activation when it is degraded by the anaphase promoting complex/cyclosome, should arrest the cell cycle after DNA damage, when it is degraded through SKP1-CUL1-βTrCP ubiquitin ligase, and its overexpression induces tumour formation and correlates with metastasis in multiple tumours. " 11/27/2014 - "The mammary tumors caused by overexpression of Separase, alone or combined with p53 heterozygosity, in mammary epithelium mimic several aspects of the most aggressive forms of human breast cancer, including high levels of genetic instability, cell cycle defects, poor differentiation, distant metastasis and metaplasia. "

Related Drugs and Biologics

1.	cohesins (cohesin)
2.	Cysteine Proteases (Cysteine Protease)
3.	Cyclin B2
4.	Cyclin B1
5.	Small Interfering RNA (siRNA)
6.	Ubiquitin
7.	Paclitaxel (Taxol)
8.	Cyclins
9.	Tetracycline (Achromycin)
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Transplants (Transplant)
3.	Hepatectomy