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SIB 1757

a selective mGluR5 antagonist; structure in first source

Also Known As:

6-methyl-2-(phenylazo)-3-pyridinol; SIB-1757; SIB1757

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Aminopyridines: 77
      - Phenazopyridine: 134
        SIB 1757: 2

Experts

1.	Chen, Peng Min: 1 article (12/2007)
2.	Lee, Wei Ling: 1 article (12/2007)
3.	Tang, Feng Ru: 1 article (12/2007)
4.	Tang, Yong Cheng: 1 article (12/2007)
5.	Tsai, Mui Chiung: 1 article (12/2007)
6.	Dogrul, A: 1 article (10/2000)
7.	Lai, J: 1 article (10/2000)
8.	Malan, T P: 1 article (10/2000)
9.	Ossipov, M H: 1 article (10/2000)
10.	Porreca, F: 1 article (10/2000)

Related Diseases

1.	Status Epilepticus (Complex Partial Status Epilepticus) 12/01/2007 - "By intravenous administration of group I metabotropic glutamate receptor antagonists at 1 or 2h during pilocarpine induced status epilepticus (PISE), we showed that mGluR1 antagonists AIDA or LY367385 (at dosages ranging from 25 to 200mg/kg), mGluR5 antagonists SIB1757 (at dosages ranging from 25 to 200mg/kg), SIB1893 (from 25 to 100mg/kg), MPEP (from 25 to 100mg/kg) injected at 1 or 2h during PISE were ineffective in controlling status epilepticus (SE). "
2.	Neuralgia (Stump Neuralgia) 10/06/2000 - "Here, the possible role of mGluR(5) receptors in experimental neuropathic pain elicited by ligation of spinal nerves (L(5)/L(6) spinal nerve ligation, SNL) was explored with SIB-1757, a selective mGluR(5) antagonist. " 10/06/2000 - "Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats."
3.	Hyperalgesia 10/06/2000 - "SIB-1757 produced full reversal of thermal hyperalgesia in SNL rats following administration either spinally or locally to the injured paw; administration to the contralateral paw had no effect. " 10/06/2000 - "SIB-1757 produced a partial reversal of tactile allodynia with a shallow dose-response curve ranging over three-orders of magnitude; SIB-1757 was inactive against allodynia when given systemically. "

Related Drugs and Biologics

1.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
2.	Pilocarpine (Ocusert)
3.	SIB 1893
4.	metabotropic glutamate receptor type 1
5.	alpha-methyl-4-carboxyphenylglycine

Related Therapies and Procedures

1.	Intravenous Administration
2.	Ligation