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EMD 61747

structure in first source

Also Known As:

EMD-61747; N-methyl-N-((1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidine-1-yl)-ethyl)-2-(2,3-dihydro-2-oxo-benzoxazol-5-yl)-acetamide HCL

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - EMD 61747: 1

Related Diseases

1.	Ischemia 03/01/1999 - "The change in the properties of the BBB in ischemic tissue was not sufficient to elicit neuroprotection, since both EMD-61747 and EMD-61569 were inactive in the focal ischemia model. " 03/01/1999 - "To do this, the actions of the peripherally selective OP2 agonists, EMD-61569 and EMD-61747, have been compared with those of the centrally acting OP2 agonist, GR-89696, in the rat permanent focal ischemia model. "
2.	Infarction (Infarctions) 03/01/1999 - "Permanent unilateral occlusion of the middle cerebral artery (MCAO) was associated with a disruption of the BBB and an increase in the concentration of EMD-61747 in the area of the infarct. " 03/01/1999 - "produced a reduction in infarct volume by 38% after MCAO, EMD-61569 and EMD-61747 had no influence on swelling and ischemic damage. "
3.	Brain Ischemia (Cerebral Ischemia) 03/01/1999 - "Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat."

Related Drugs and Biologics

1.	EMD 61569
2.	GR 89696