matadine

from roots of Strychnos gossweileri; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Poisoning 06/15/1999 - "All three compounds stabilize the topoisomerase II-DNA covalent complex and stimulate the cutting of DNA by topoisomerase II. The poisoning effect is more pronounced with cryptolepine than with matadine and serpentine, but none of the drugs exhibit a preference for cutting at a specific base. "
2.	Experimental Melanoma 06/15/1999 - "Cryptolepine which binds 10-fold more tightly to DNA than the two related alkaloids proves to be much more cytotoxic toward B16 melanoma cells than matadine and serpentine. "
3.	Melanoma (Melanoma, Malignant) 11/01/1999 - "However, its capacity to inhibit nucleic acids synthesis in melanoma cells, on the one hand, and its structural analogy with DNA-binding pyridoindole plant alkaloids recently studied (cryptolepine and matadine), on the other hand, suggested that usambarensine could also bind to DNA. "
4.	Leukemia 11/01/1999 - "Biochemical experiments indicated that, in contrast to cryptolepine and matadine, usambarensine does not interfere with the catalytic activity of topoisomerase II. Human HL60 leukemia cells were used to assess the cytotoxicity of the alkaloid and its effect on the cell cycle. "

1.	Type II DNA Topoisomerases (Topoisomerase II)
2.	DNA (Deoxyribonucleic Acid)
3.	Alkaloids
4.	cryptolepine
5.	Nucleic Acids
6.	usambarensine
7.	serpentine (alkaloid)