coactivator-associated arginine methyltransferase 1

05/10/2013 - "We previously showed that twofold overexpression of CARM1 in MCF7 breast cancer cells increased the expression of ERα-target genes involved in differentiation and reduced cell proliferation, thus leading to the hypothesis that activating CARM1 by chemical activators might be therapeutically effective in breast cancer. "
07/01/2013 - "Outcome analyses indicate that CARM1 expression is an independent predictor of shorter breast cancer-specific survival and disease-free interval in the whole series and in the ER-positive subgroup. "
01/01/2020 - "Conclusions: our study uncovered a "hypermethylation" strategy utilized by enhancer-bound CARM1 in gene transcriptional regulation, and suggested that CARM1 can server as a therapeutic target for breast cancer treatment."
06/04/2019 - "Previous studies establish an oncogenic function of CARM1 in the context of colorectal and breast cancer, which correlate to its overexpressed condition. "
10/15/2020 - "Correction: A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion."

11/01/2018 - "Finally, we utilize a selective, small-molecule inhibitor of CARM1 to validate the efficacy of CARM1 inhibition in leukemia cells in vitro and in vivo. "
07/08/2020 - "The majority of 4a-n exhibited potent dual p300 and CARM1 inhibition, sometimes reaching the submicromolar level, and induction of apoptosis mainly in the tested leukemia cell lines. "
11/01/2008 - "c-Abl (v-Abl Abelson murine leukemia viral oncogene homolog 1) tyrosine kinase directly phosphorylates AIB1/SRC-3 at Y1357 and modulates the association of AIB1 with c-Abl, ERalpha, the transcriptional cofactor p300, and the methyltransferase coactivator-associated arginine methyltransferase 1, CARM1. "

01/01/2023 - "Recently, accumulating studies have demonstrated the oncogenic role of CARM1 in many types of human cancers. "
12/21/2017 - "CARM1 overexpression has been reported in multiple cancer types and has been shown to modulate oncogenic pathways in in vitro studies. "
05/13/2010 - "The goal of this study was to confirm the pattern of expression of CARM1 in human tumors and determine the mechanism of action in CARM1 overexpressed tumors. "
11/09/2023 - "Inhibition of CARM1 can increase the sensitivity of tumor cells to ferroptosis inducers in vitro and in vivo. "
09/28/2023 - "CARM1 degradation by 3b resulted in potent downregulation of CARM1 substrate methylation and inhibition of cancer cell migration in cell-based assays. "

12/21/2017 - "Detailed understanding of the mechanism of action of CARM1 in oncogenesis has been limited by a lack of selective tool compounds, particularly for in vivo studies. "
01/01/2022 - "CARM1 level in OSCC cells was significantly inhibited by WDR5 downregulation, and CARM1 elevation could rescue the effect of WDR5 knockdown on tumorigenesis of OSCC. "
06/04/2019 - "Functional interplay between YY1 and CARM1 promotes oral carcinogenesis."
01/01/2019 - "To address the possible roles of PRMT overexpression in mammary gland tumorigenesis, we generated Cre-activated PRMT1, CARM1, and PRMT6 overexpression mouse models. "
11/29/2017 - "Erratum: PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis."

01/01/2023 - "The purpose of this study was to characterize the effects of short-term, pharmacological CARM1 inhibition on skeletal muscle size, function, and atrophy. "
11/29/2023 - "CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy."
01/01/2023 - "Furthermore, skeletal muscle atrophy and autophagy gene expression programs were elevated in response to DEN independent of CARM1 suppression. "
01/01/2023 - "Impact of short-term, pharmacological CARM1 inhibition on skeletal muscle mass, function, and atrophy in mice."
01/01/2019 - "Furthermore, CARM1 knockdown induces a remarkable myofiber autophagic deficit during the atrophy process. "