2-fluoro-3-(2-azetidinylmethoxy)pyridine

a nicotinic acetylcholine receptor ligand; structure in first source

Also Known As:

18F-fluoro-A-85380; 2-(18)F-fluoro-3(2(S)-2-azetidinylmethoxy)pyridine; 2-(18F)F-A85380; 2-(18F)fluoro-A-85380; F-A 85380; F-A-85380; F-fluoro-A-85380

Networked: 5 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 2-fluoro-3-(2-azetidinylmethoxy)pyridine: 5
  - Azetines
    - Azetidines: 6
      - 2-fluoro-3-(2-azetidinylmethoxy)pyridine: 5

Experts

1.	Brust, Peter: 2 articles (03/2008 - 03/2008)
2.	Kendziorra, Kai: 2 articles (03/2008 - 03/2008)
3.	Sabri, Osama: 2 articles (03/2008 - 03/2008)
4.	Garibotto, Valentina: 1 article (01/2019)
5.	Giavri, Zoi: 1 article (01/2019)
6.	Goldstein, Rachel: 1 article (01/2019)
7.	Haller, Sven: 1 article (01/2019)
8.	Picard, Fabienne: 1 article (01/2019)
9.	Ratib, Osman: 1 article (01/2019)
10.	Seeck, Margitta: 1 article (01/2019)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2017 - "Cholinergic Changes in Aging and Alzheimer Disease: An [18F]-F-A-85380 Exploratory PET Study." 03/01/2008 - "To clarify whether changes in the cholinergic transmission occur early in the course of Alzheimer's disease (AD), we carried out positron emission tomography (PET) with the radioligand 2-[(18)F]F-A-85380, which is supposed to be specific for alpha4beta2 nicotinic acetylcholine receptors (nAChRs). "
2.	Dementia (Dementias) 03/01/2008 - "Recent studies demonstrate the applicability of the nAChR ligand 2-[(18)F]F-A-85380 for neuroimaging of patients with dementias. "
3.	Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 08/01/2006 - "PET study using [18F]-F-A-85380, a high affinity agonist at the alpha4beta2 nAChRs, allows the determination of the regional distribution and density of the nAChRs in healthy volunteers and in ADNFLE patients, thus offering a unique opportunity to investigate some in vivo consequences of the molecular defect. " 08/01/2006 - "We have assessed nAChR distribution in eight non-smoking ADNFLE patients (from five families) bearing an identified mutation in nAChRs and in seven age-matched non-smoking healthy volunteers using PET and [(18)F]-F-A-85380. "
4.	Partial Epilepsies (Epilepsy, Partial) 01/01/2019 - "At an individual level, F-A-85380 BPRI increase in the ACC could distinguish IGE patients from controls and from patients with focal epilepsy with good accuracy. "

Related Drugs and Biologics

1.	Cholinergic Agents (Cholinergics)
2.	Ligands
3.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
4.	Immunoglobulin E (IgE)