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M 50367

structure in first source

Also Known As:

M50367

Networked: 3 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - M 50367: 3

Experts

1.	Kato, Yutaka: 2 articles (01/2005 - 07/2003)
2.	Mizuguchi, Kiyoshi: 2 articles (01/2005 - 07/2003)
3.	Mochizuki, Hidenori: 2 articles (01/2005 - 07/2003)
4.	Furusako, Shoji: 1 article (07/2003)
5.	Negishi, Takaaki: 1 article (07/2003)

Related Diseases

1.	Asthma (Bronchial Asthma) 06/15/1999 - "These results suggest that M50367 has a modulating ability of Th1/Th2 balance to down-regulate Th2 response in the circulating system as well as at the sites of inflammation, and may be beneficial for the treatment of allergic disorders such as atopic asthma." 06/15/1999 - "In this study, we evaluated the ability of M50367 to modulate Th1/Th2 balance in Th2-background BALB/c mice and to inhibit airway hyperresponsiveness in a murine model of atopic asthma. " 07/01/2003 - "We previously reported an orally active anti-allergic agent, M50367, modulated Th1/Th2 balance to down-regulate Th2 response in a murine model of atopic asthma. "
2.	Inflammation (Inflammations) 06/15/1999 - "These results suggest that M50367 has a modulating ability of Th1/Th2 balance to down-regulate Th2 response in the circulating system as well as at the sites of inflammation, and may be beneficial for the treatment of allergic disorders such as atopic asthma."
3.	Respiratory Hypersensitivity 06/15/1999 - "In this study, we evaluated the ability of M50367 to modulate Th1/Th2 balance in Th2-background BALB/c mice and to inhibit airway hyperresponsiveness in a murine model of atopic asthma. " 06/15/1999 - "Effect of an orally active Th1/Th2 balance modulator, M50367, on IgE production, eosinophilia, and airway hyperresponsiveness in mice."
4.	Neoplasms (Cancer) 01/01/2005 - "In this study, we investigated the effect of M50367 on 2 other murine disease models, such as atopic dermatitis and intradermal tumor-bearing mice, the pathogenesis of which may be related to the Th2 response. " 01/01/2005 - "In C57BL/6 mice bearing intradermal B16F10 melanoma, M50367 (30, 100 mg/kg) significantly inhibited splenomegaly and enhanced spontaneous interferon-gamma release from cultured splenocytes in a dose-dependent manner, though its effect on tumor volume was limited. "
5.	Atopic Dermatitis (Atopic Eczema) 01/01/2005 - "In this study, we investigated the effect of M50367 on 2 other murine disease models, such as atopic dermatitis and intradermal tumor-bearing mice, the pathogenesis of which may be related to the Th2 response. " 01/01/2005 - "A novel benzoimidazole derivative, M50367, modulates helper T type I/II responses in atopic dermatitis mice and intradermal melanoma-bearing mice."

Related Drugs and Biologics

1.	Anti-Allergic Agents (Antiallergic Agents)
2.	Interferon-gamma (Interferon, gamma)
3.	Immunoglobulin E (IgE)
4.	Acetylcholine (Acetylcholine Chloride)