(diaminocyclohexane)(diacetato)(dichloro)platinum

antineoplastic; structure in first source

Also Known As:

(1R,2R-diaminocyclohexane)(trans-diacetato)(dichloro)platinum(IV); (Pt(IV)(1,2-diaminocyclohexane)(acetate)2Cl2); DACH-acetato-Pt; DAP platinum cpd

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 03/01/1999 - "In view of the central role of the wild-type p53 tumor suppressor gene in drug-induced apoptosis, we evaluated the cytotoxicity of cisplatin and DACH-acetato-Pt in a panel of cisplatin-resistant ovarian tumor models with differing p53 status. " 11/01/2001 - "1R,2R-Diaminocyclohexane(trans-diacetato)(dichloro)-platinum(IV) (DACH-acetato-Pt) is a novel platinum-based agent that is highly effective against cisplatin-resistant ovarian tumor cells. " 03/01/1999 - "In particular, the greater activity of DACH-acetato-Pt in cisplatin-resistant wild-type p53 ovarian tumor models can be ascribed to its ability to more efficiently induce p53 protein and activate p53 functions."
2.	Ovarian Neoplasms (Ovarian Cancer) 11/01/2001 - "To probe its cellular mechanism, the effects of DACH-acetato-Pt (0-6.4 microM) on cell cycle checkpoints were examined using the ovarian cancer A2780 cell line as the model system. "