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protein phosphatase methylesterase-1

demethylates protein phosphatase 2A catalytic subunit (PP2A C subunit); amino acid sequence in first source
Also Known As:
PME-1 enzyme; PP2A methylesterase
Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Bachovchin, Daniel A: 2 articles (07/2011 - 04/2011)
2. Cravatt, Benjamin F: 2 articles (07/2011 - 04/2011)
3. Rosen, Hugh: 2 articles (07/2011 - 04/2011)
4. Speers, Anna E: 2 articles (07/2011 - 04/2011)
5. Avoranta, Tuulia: 1 article (12/2015)
6. Birkman, Eva-Maria: 1 article (12/2015)
7. Elzagheid, Adam: 1 article (12/2015)
8. Kaur, Amanpreet: 1 article (12/2015)
9. Korkeila, Eija: 1 article (12/2015)
10. Kytölä, Ville: 1 article (12/2015)

Related Diseases

1. Neoplasms (Cancer)
07/27/2023 - "Protein phosphatase methylesterase-1 (PME-1), a regulator of the tumor suppressive phosphatase PP2A, promotes PP2A demethylation and inactivation, and is overexpressed in 44% of GBM, associated with increased tumor grade and cellular proliferation. "
01/01/2022 - "PP2A methylesterase 1 (PME-1) is a cancer-promoting enzyme and undergoes methylesterase activation upon binding to the PP2A core enzyme. "
04/26/2011 - "Here, we describe the outcome of an inhibitor screen for one such target, the enzyme protein phosphatase methylesterase-1 (PME-1), which regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration. "
07/28/2011 - "The serine hydrolase protein phosphatase methylesterase-1 (PME-1) regulates the methylesterification state of protein phosphatase 2A (PP2A) and has been implicated in cancer and Alzheimer's disease. "
01/01/2014 - "The present article summarises new data published during the last decade dedicated to the design, synthesis and biological exploration of new β-lactams with anti-inflammatory, antiviral, anticancer and other activities based on the inhibition of human leukocyte elastase, porcine pancreatic elastase, tryptase, chymase, human cytomegalovirus protease, fatty acid amide hydrolase, protein phosphatase methylesterase-1, serine protease responsible for tumor proliferation, cysteine proteases, matrix metalloproteinases, human 20s proteasome, human immunodeficiency virus, cholesterol absorption, human fatty acid synthase, bacterial RNase A and Leishmania D-mannosyl phosphate transferase. "
2. Colorectal Neoplasms (Colorectal Cancer)
3. Prostatic Neoplasms (Prostate Cancer)
4. Alzheimer Disease (Alzheimer's Disease)

Related Drugs and Biologics

1. Protein Phosphatase 2 (Protein Phosphatase 2A)
2. Enzymes
3. Fatty Acid Synthases (Fatty Acid Synthase)
4. Serine Proteases (Serine Protease)
5. Cysteine Proteases (Cysteine Protease)
6. Chymases (Chymase)
7. Tryptases (Tryptase)
8. Proteasome Endopeptidase Complex (Proteasome)
9. Matrix Metalloproteinases (MMPs)
10. Leukocyte Elastase (Neutrophil Elastase)

Related Therapies and Procedures

1. Therapeutics