HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

OPB 3206

structure in first source

Also Known As:

3S-(4-(N-hydroxyamino)-2R-isobutylsuccinyl)amino-1-methoxy-3,4-dihydrocarbostyril; OPB-3206; OPB3206

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        OPB 3206: 3

Related Diseases

1.	Neoplasms (Cancer) 01/01/1998 - "The anti-angiogenic effect of OPB-3206 appeared to be associated with its inhibition of tumor growth and metastasis." 03/01/1999 - "When OPB-3206 was orally administered at 0%, 0.1% and 0.4% in the diet for 4 weeks, starting 7 days after subcutaneous transplantation of osteosarcomas to male Fischer 344 rats, numbers of lung metastatic nodules were significantly reduced by the highest dose, while the growth of subcutaneous tumors was not affected. "
2.	Neoplasm Metastasis (Metastasis) 03/01/1999 - "The results thus suggest that OPB-3206 selectively inhibits lung metastasis of rat transplantable osteosarcomas by inhibiting MMP-9 activation." 01/01/1998 - "The anti-angiogenic effect of OPB-3206 appeared to be associated with its inhibition of tumor growth and metastasis." 03/01/1999 - "In the present experiment, we examined the effects of OPB-3206, 3S-[4-(N-hydroxyamino)-2R-isobutylsuccinyl]amino-1-methoxy-3,4- dihydrocarbostyril, a novel metalloproteinase inhibitor, on the growth and metastasis of transplantable osteosarcomas (spontaneous osteosarcoma, selected lung metastatic lesions; S-SLM), which were previously established in rats. "
3.	Osteosarcoma (Osteogenic Sarcoma) 03/01/1999 - "The results thus suggest that OPB-3206 selectively inhibits lung metastasis of rat transplantable osteosarcomas by inhibiting MMP-9 activation." 03/01/1999 - "When OPB-3206 was orally administered at 0%, 0.1% and 0.4% in the diet for 4 weeks, starting 7 days after subcutaneous transplantation of osteosarcomas to male Fischer 344 rats, numbers of lung metastatic nodules were significantly reduced by the highest dose, while the growth of subcutaneous tumors was not affected. " 03/01/1999 - "In the present experiment, we examined the effects of OPB-3206, 3S-[4-(N-hydroxyamino)-2R-isobutylsuccinyl]amino-1-methoxy-3,4- dihydrocarbostyril, a novel metalloproteinase inhibitor, on the growth and metastasis of transplantable osteosarcomas (spontaneous osteosarcoma, selected lung metastatic lesions; S-SLM), which were previously established in rats. "
4.	Pancreatic Neoplasms (Pancreatic Cancer) 07/01/1999 - "Gelatin zymography demonstrated that OPB-3206 inhibited activation of proMMP-2 in pancreatic cancer tissues. "
5.	Carcinoma (Carcinomatosis) 07/01/1999 - "In our rapid production model, 0.1 and 0.2% OPB-3206, an inhibitor of MMPs, given in the diet after two cycles of augmentation pressures for 48 days decreased the incidence and number of carcinomas. "

Related Drugs and Biologics

1.	Metalloproteases (Metalloproteinases)
2.	Matrix Metalloproteinases (MMPs)
3.	Gelatin
4.	progelatinase

Related Therapies and Procedures

1.	Transplantation