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endobain E

an ouabain-like factor from a brain soluble fraction (peak II)

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cardanolides
      - Cardiac Glycosides: 1002
        Cardenolides: 137
        Strophanthins: 181
        Ouabain: 2233
        endobain E: 2
Carbohydrates: 22023
- Glycosides: 2119
  - Cardiac Glycosides: 1002
    - Strophanthins: 181
      - Ouabain: 2233
        endobain E: 2

Experts

1.	Carmona, C: 1 article (12/2005)
2.	Negri, G: 1 article (12/2005)
3.	Peña, C: 1 article (12/2005)
4.	Reinés, A: 1 article (12/2005)
5.	Rodríguez de Lores Arnaiz, G: 1 article (12/2005)
6.	Zárate, S: 1 article (12/2005)
7.	Pellegrino de Iraldi, Amanda: 1 article (04/2003)
8.	Peña, Clara: 1 article (04/2003)
9.	Rodríguez de Lores Arnaiz, Georgina: 1 article (04/2003)

Related Diseases

1.	Ischemia 12/05/2005 - "On the other hand, endobain E prepared from rats without treatment also decreased binding to cerebral cortex or hippocampal membranes obtained from animals exposed to ischemia-reperfusion. " 12/05/2005 - "Elution profile of brain soluble fraction showed that endobain E is present in cerebral cortex of ischemia-reperfusion rats. " 12/05/2005 - "In the present study we investigated whether endobain E is present in the cerebral cortex of rats subjected to ischemia and modulates NMDA receptor exposed to the same conditions. " 12/05/2005 - "Since ischemia decreases tissue pH and NMDA receptor activity varies according to proton concentration, pH influence on endobain E effect was tested. "
2.	Body Weight (Weight, Body) 04/01/2003 - "1. The purpose of the present study was to analyze the possible effect of ouabain and an endogenous ouabain-like substance (endobain E), on lenses of 100- and 400-g body weight rats. "
3.	Brain Ischemia (Cerebral Ischemia) 12/05/2005 - "These results demonstrate that endobain E is present and also able to modulate NMDA receptor in the short-term period that follows cerebral ischemia and that its effect depends on proton concentration, suggesting greater NMDA receptor modulation by endobain E at low pH, typical of ischemic tissues."

Related Drugs and Biologics

1.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
2.	Ouabain (G Strophanthin)
3.	Protons (Proton)

Related Therapies and Procedures

1.	Lenses