TEI 8362

inhibitor of human neutrophil elastase; structure in first source

Also Known As:

4-(N-(3-((3-carboxypropyl)amino)-8-methyl-oxo-4-azaisochromen-6-yl)carbamoyl)-4-((phenylmethoxy)carbonylamino)butanoic acid; TEI-8362

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Ohbayashi, Hiroyuki: 1 article (07/2002)

1.	Lung Injury 03/01/1999 - "In this model, lung injury was significantly attenuated by i.t., i.v., or inhalant administration of TEI-8362. "
2.	Chronic Obstructive Pulmonary Disease (COPD) 07/01/2002 - "In the application of chronic obstructive pulmonary disease therapy, the human neutrophil elastase inhibitors mainly focused upon include ONO-5046, MR-889, L-694,458, CE-1037, GW-311616 and TEI-8362 as the acyl-enzyme inhibitors; and ONO-6818, AE-3763, FK-706, ICI-200,880, ZD-0892 and ZD-8321 as the transition-state inhibitors. "
3.	Lung Diseases (Lung Disease) 03/01/1999 - "5. These pharmacological actions of TEI-8362 suggest that this drug has therapeutic value in the treatment of destructive lung diseases due to neutrophils."

1.	Secretory Proteinase Inhibitory Proteins
2.	Enzyme Inhibitors (Inhibitors, Enzyme)
3.	N- ((3- (carboxymethyl)- 2- oxoimidazolidin- 1- yl)acetyl)- l- valyl- N- ((3S)- 1,1,1- trifluoro- 4- methyl- 2- oxopentan- 3- yl)- l- prolinamide
4.	ONO 6818
5.	ZD 0892
6.	ZD 8321
7.	DMP 777
8.	MDL 201,404YA
9.	sivelestat
10.	midesteine

1.	Therapeutics