NSC 652287

RITA - reactivation of p53 and induction of tumor cell apoptosis; has antineoplastic activity; structure in first source

Also Known As:

2,5-bis(5-hydroxymethyl-2-thienyl)furan; 5,5'-(2,5-furandiyl)bis-2-thiophenemethanol; RITA compound; small molecule RITA

Networked: 16 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - NSC 652287: 16

Experts

1.	Selivanova, Galina: 6 articles (09/2021 - 12/2004)
2.	Burmakin, Mikhail: 2 articles (09/2021 - 09/2013)
3.	Hedström, Elisabeth: 2 articles (09/2021 - 09/2013)
4.	Kogner, Per: 2 articles (09/2021 - 09/2013)
5.	Shi, Yao: 2 articles (09/2021 - 09/2013)
6.	Booth, Samuel: 1 article (02/2020)
7.	Mai, Sabine: 1 article (02/2020)
8.	Rangel-Pozzo, Aline: 1 article (02/2020)
9.	Singh, Madhurendra: 1 article (02/2020)
10.	Yu, Pak Lok Ivan: 1 article (02/2020)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2015 - "A recent study demonstrated that small-molecule RITA (reactivation of p53 and induction of tumor cell apoptosis) increased the radiosensitivity of tumor cells expressing mutant p53 (mtp53). " 09/20/2005 - "Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer." 12/01/2004 - "Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors." 02/22/2020 - "Moreover, we demonstrate that another p53 stabilizing small molecule, RITA (reactivation of p53 and induction of tumor cell apoptosis), also induces changes in 3D DNA structure, apparently in a p53 independent manner. " 12/01/2012 - "We evaluated whether the restoration of p53 function by the p53-reactivating small molecule RITA (reactivation of p53 and induction of tumor cell apoptosis enhances cisplatin-induced cytotoxicity and apoptosis in head-and-neck cancer (HNC). "
2.	Rhabdomyosarcoma 01/01/2019 - "In this study, we demonstrate that the small molecule RITA, a p53 activator, effectively downregulates HH signaling in human medulloblastoma and rhabdomyosarcoma cells irrespective of p53. "
3.	Medulloblastoma 01/01/2019 - "In this study, we demonstrate that the small molecule RITA, a p53 activator, effectively downregulates HH signaling in human medulloblastoma and rhabdomyosarcoma cells irrespective of p53. "
4.	Neuroblastoma 09/01/2021 - "Editor's Note: Dual Targeting of Wild-Type and Mutant p53 by Small-molecule RITA Results in the Inhibition of N-Myc and Key Survival Oncogenes and Kills Neuroblastoma Cells In Vivo and In Vitro." 09/15/2013 - "Here, we addressed the question whether small molecule RITA can reactivate p53 in neuroblastoma and suppress the growth of neuroblastoma cells in vitro and in vivo. " 09/15/2013 - "Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro."
5.	Head and Neck Neoplasms (Head and Neck Cancer) 01/01/2014 - "The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells." 12/01/2012 - "The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer." 12/01/2012 - "We evaluated whether the restoration of p53 function by the p53-reactivating small molecule RITA (reactivation of p53 and induction of tumor cell apoptosis enhances cisplatin-induced cytotoxicity and apoptosis in head-and-neck cancer (HNC). "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Thiophenes
3.	Proteins (Proteins, Gene)
4.	DNA (Deoxyribonucleic Acid)
5.	furan
6.	Dihydrotachysterol (AT 10)
7.	Cisplatin (Platino)