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axokine

a human ciliary neurotrophic factor (CNTF) analog

Also Known As:

recombinant ciliary neurotrophic factor, human; rhvCNTF, human

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Watt, Matthew J: 2 articles (01/2016 - 05/2006)
2.	Andrews, Zane B: 1 article (01/2016)
3.	Borg, Melissa L: 1 article (01/2016)
4.	Lemus, Moyra: 1 article (01/2016)
5.	Oldfield, Brian J: 1 article (01/2016)
6.	Reichenbach, Alex: 1 article (01/2016)
7.	Febbraio, Mark A: 1 article (05/2006)
8.	Hevener, Andrea: 1 article (05/2006)
9.	Lancaster, Graeme I: 1 article (05/2006)
10.	Garcia, K: 1 article (11/2003)

Related Diseases

1.	Obesity 02/01/2002 - "AXOKINE is a 22-kDa protein currently in clinical trials as a therapeutic for obesity associated with diabetes. " 07/01/2003 - "Axokine, a second-generation neurotrophic factor that is related to ciliary neurotrophic factor (CNTF), is under development by Regeneron for the potential treatment of obesity and associated complications such as type 2 diabetes."
2.	Insulin Resistance 01/01/2016 - "Instead, a rapid rebound in food intake and body mass occurred immediately after cessation of Axokine treatment, and this tended to reduce insulin sensitivity. " 05/01/2006 - "To avoid confounding effects of long-term high-fat feeding or genetic manipulation on whole-body insulin sensitivity, we performed a 2-h Intralipid infusion (20% heparinized Intralipid) with or without recombinant CNTF pretreatment (Axokine 0.3 mg/kg), followed by a 2-h hyperinsulinemic-euglycemic clamp (12 mU/kg.min) in fasted, male Wistar rats. "
3.	Type 2 Diabetes Mellitus (MODY) 11/25/2003 - "We therefore examined the effects of a modified form of ciliary neurotrophic factor [Axokine, which is hereafter referred to as ciliary neurotrophic factor (CNTF)Ax15], which uses a leptin-like mechanism to reduce body weight, in the db/db murine model of type 2 diabetes. " 07/01/2003 - "Axokine, a second-generation neurotrophic factor that is related to ciliary neurotrophic factor (CNTF), is under development by Regeneron for the potential treatment of obesity and associated complications such as type 2 diabetes."
4.	Weight Loss (Weight Reduction) 01/01/2016 - "Short-term administration of Axokine induced an anorexic response but did not promote sustained weight loss. "
5.	Retinal Degeneration 05/01/1999 - "Axokine, but not BDNF, delays photoreceptor loss in this hereditary retinal degeneration. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Ciliary Neurotrophic Factor (CNTF)
3.	Leptin
4.	Brain-Derived Neurotrophic Factor (BDNF)
5.	Retinaldehyde (Retinal)
6.	Nerve Growth Factors (Neurotrophins)
7.	Glucose (Dextrose)
8.	Bromodeoxyuridine (BrdU)
9.	phospholipid emulsion soybean oil (Intralipid)