alpha 2(I) collagen

01/01/2010 - "Eight genes involved in bone metabolism or pathology (COL1A1, COL1A2, OPG, ESR1, VDR, CTR, LRP5, IL-6) were examined in 72 military conscripts with a femoral neck stress fracture and 120 controls. "
01/01/2012 - "Twenty-five polymorphisms within 9 genes (NR3C1, ANKH, VDR, ROR2, CALCR, IL6, COL1A2, CBG, and LRP4) showed statistically significant differences (p < 0.05) in the distribution between stress fracture cases and non stress fracture controls. "

09/01/2015 - "To investigate the role of ITGAV in the skin fibrosis, we engineered transgenic mice that overexpress ITGAV in the fibroblasts under the control of the COL1A2 enhancer promoter. "
08/28/2015 - "Vascular smooth muscle cell-specific overexpression of Runx2 in transgenic mice increases expression of its target genes, Col1a1 and Col1a2, leading to medial fibrosis and aortic stiffening. "
01/01/2012 - "In addition to p21/Cip1, we observed HIV associated upregulation of the senescence factor p16INK4a (CDKN2A) and fibrosis associated TGFβ1, CTGF, COL1A1 and COL1A2. "
09/01/2011 - "Here, we report that de-novo transcription of the COL1A2 gene occurred predominantly in damaged tubular epithelial cells during progressive interstitial fibrosis in vivo. "
09/01/2011 - "Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivo."

11/01/2015 - "Mutation spectrum of COL1A1 and COL1A2 genes in Indian patients with osteogenesis imperfecta."
10/06/2015 - "However, in the severe mouse model of osteogenesis imperfecta (OIM), deletion of the COL1A2 gene results in the substitution of the α2(I) chain by one α1(I) chain. "
01/01/2015 - "Genetic screening of a pedigree with osteogenesis imperfecta type Ⅰ and identification of a novel mutation in COL1A2 pathogenic gene."
10/01/2014 - "Analyses of iliac bone samples revealed no major abnormalities in bone mineralization density distribution, an indicator of material bone properties, whereas a shift towards higher bone mineralization density is characteristic of classical osteogenesis imperfecta caused by mutations in COL1A1/COL1A2. "
06/01/2014 - "Mutation spectrum of COL1A1 and COL1A2 genes in Indian patients with osteogenesis imperfecta."

07/01/2009 - "In this study, we investigated whether the rs42524 and rs2621215 polymorphisms of the COL1A2 gene are associated with the development of cerebral aneurysms in the Korean population. "
02/01/2014 - "The COL1A2 gene is associated with intracranial aneurysms in a subset of the German population. "
12/01/2012 - "The COL1A2 gene on chromosome 7q22.1 has been shown to be associated with intracranial aneurysms. "
07/10/2009 - "A coding polymorphism (rs42524) in COL1A2 has previously been associated with intracranial aneurysms. "
12/01/2008 - "The COL1A2 gene at 7q22.1 has been shown to be associated with familial intracranial aneurysms (IAs) in the Japanese population. "

06/25/1988 - "Recent biochemical studies have shown that the fibroblasts from a patient with Ehlers-Danlos Syndrome Type VIIB produce nearly equal amounts of normal and shortened pro-alpha 2(I) collagen chains (Wirtz, M.K., Glanville, R. "
03/15/2014 - "The first Japanese case of the arthrochalasia type of Ehlers-Danlos syndrome with COL1A2 gene mutation."
04/01/1994 - "The features of a 32 year old woman with Ehlers-Danlos syndrome type VIIB and affected members of her family, resulting from a mutation in one COL1A2 allele, were studied. "
05/05/1992 - "We have shown that a child with Ehlers Danlos syndrome (EDS) type VII has a G to A transition at the first nucleotide of intron 6 in one of her COL1A2 alleles. "
12/01/1991 - "Exclusion of COL1A1, COL1A2, and COL3A1 genes as candidate genes for Ehlers-Danlos syndrome type I in one large family."