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N- ((1,3- dimethylindole- 2- carbonyl)- valinyl)- 3- amino- 4- oxo- 5- fluoropentanoic acid

structure in first source

Also Known As:

IDN 1965; IDN-1965; IDN1965

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - N-((1,3-dimethylindole-2-carbonyl)-valinyl)-3-amino-4-oxo-5-fluoropentanoic acid: 2
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - N-((1,3-dimethylindole-2-carbonyl)-valinyl)-3-amino-4-oxo-5-fluoropentanoic acid: 2

Experts

1.	Burikhanov, R: 1 article (06/2001)
2.	D'Souza, N B: 1 article (06/2001)
3.	Deaciuc, I V: 1 article (06/2001)
4.	Hill, D B: 1 article (06/2001)
5.	McClain, C J: 1 article (06/2001)
6.	Sarphie, T G: 1 article (06/2001)
7.	de Villiers, W J: 1 article (06/2001)

Related Diseases

1.	Shock 09/01/1999 - "Two novel caspase inhibitors, (2-indolyl)-carbonyl-Ala-Asp-fluoromethylketone (IDN 1529) and (1-methyl-3-methyl-2-indolyl)-carbonyl-Val-Asp-fluoromethylketone (IDN 1965), were studied in a murine model of endotoxic shock. " 09/01/1999 - "Paradoxically, administration of IDN 1529 but not IDN 1965 led to an increase in the LPS-induced elevation of serum cytokines related directly (IL-1beta, IL-18) or indirectly (IL-1alpha, IL-1Ra) to the action of caspase 1. A process that appears to be distinct from both apoptosis and the release of inflammatory cytokines is a late-acting requirement for lethality in endotoxic shock. "
2.	Necrosis 06/01/2001 - "IDN1965 also abolished the increase in TUNEL-positive nuclei, reversed the effect of LPS on plasma AST in alcohol-treated rats, and prevented LPS-induced necrosis. "
3.	Body Weight (Weight, Body) 06/01/2001 - "Rats were fed a high-fat, alcohol-containing liquid diet for 14 weeks, treated with LPS (1.0 mg/kg of body weight, intravenously) or saline, followed by injection of a pan-caspase inhibitor IDN1965; N-[(1,3-dimethylindole-2-carbonyl)-valinyl]-3-amino-4-oxo-5-fluoropentanoic acid; 10 mg/kg of body weight, intraperitoneally or vehicle, and killed. "

Related Drugs and Biologics

1.	Caspase Inhibitors
2.	Caspase 1 (ICE Protease)
3.	Caspases
4.	Cytokines
5.	Acids
6.	IDN 1529