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N(1)- ethyl- N- (11)- ((cycloheptyl)methyl)- 4,8- diazaundecane

structure in first source

Also Known As:

CHENSpm

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - N(1)-ethyl-N-(11)-((cycloheptyl)methyl)-4,8-diazaundecane: 3

Experts

1.	Casero, R A: 2 articles (02/2001 - 01/2000)
2.	Davidson, N E: 2 articles (02/2001 - 01/2000)
3.	Woster, P M: 2 articles (02/2001 - 01/2000)
4.	Casero, Robert A: 1 article (05/2002)
5.	Gerner, Eugene W: 1 article (05/2002)
6.	Lawson, Kathryn R: 1 article (05/2002)
7.	Linehan, Jennifer A: 1 article (05/2002)
8.	Marek, Sarah: 1 article (05/2002)
9.	Payne, Claire M: 1 article (05/2002)
10.	Woster, Patrick M: 1 article (05/2002)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2002 - "Because other studies suggest that PAO may be self-regulated in some tumors, differential expression of PAO may be the basis for selective toxicity of CHENSpm and other N-substituted polyamine analogues in certain cancers."
2.	Breast Neoplasms (Breast Cancer) 02/01/2001 - "This study evaluates the ability of two polyamine analogues, N1-ethyl-N11-[(cyclopropyl)methyl]-4,8-diazaundecane (CPENSpm) and N1-ethyl-N11-[(cycloheptyl)methyl]-4,8-diazaundecane (CHENSpm) to synergize with cytotoxics in five human breast cancer cell lines. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2000 - "The unsymmetrically alkylated polyamine analogues N1-ethyl-N11-((cyclopropyl)methyl)-4,8-diazaunde-cane (CPENSpm) and N1-ethyl-N11-((cycloheptyl)methyl)-4,8-diazaundecane (CHENSpm) have been shown previously to have cytotoxic effects in breast and non-small cell lung cancer cells. "

Related Drugs and Biologics

1.	Polyamines
2.	N(1)- ethyl- N- (11)- ((cyclopropyl)methyl)- 4,8- diazaundecane- 1,11- diamine