correolide

from Costa Rican tree, Spachea correae; selectively inhibits voltage-gated potassium channel Kv1.3 in human T lymphocytes by membrane depolarization

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dick, Gregory M: 1 article (01/2016)
2.	Fu, Lijuan: 1 article (01/2016)
3.	Goodwill, Adam G: 1 article (01/2016)
4.	Herring, B Paul: 1 article (01/2016)
5.	Kassab, Ghassan S: 1 article (01/2016)
6.	Noblet, Jillian N: 1 article (01/2016)
7.	Rottgen, Trey S: 1 article (01/2016)
8.	Sassoon, Daniel: 1 article (01/2016)
9.	Schepers, Luke: 1 article (01/2016)
10.	Tune, Johnathan D: 1 article (01/2016)

Related Diseases

1.	Hypertension (High Blood Pressure) 07/01/2009 - "In contrast, arteries from spontaneously hypertensive rats (SHR) and aortic-banded (Ao-B) rats with chronic hypertension showed enhanced Ca(2+)-dependent tone and failed to significantly constrict to correolide or psora-4, implying a loss of K(V)1 channel-mediated vasodilation. "
2.	Hyperemia 01/01/2016 - "Coronary artery occlusions (15 s) elicited reactive hyperemia and correolide (3 µM) reduced the flow volume repayment by approximately 30 % (P < 0.05). "
3.	Hypoxia (Hypoxemia) 08/06/2004 - "The hypoxia-sensitive, correolide-insensitive I(K) (15%) was conducted by Kv2.1. Anti-Kv1.5 and anti-Kv2.1 caused additive depolarization in resistance PASMCs (Kv1.5>Kv2.1) and inhibited hypoxic depolarization. " 08/06/2004 - "In resistance PASMCs, 4-AP and hypoxia inhibited I(K) 57% and 49%, respectively, versus 34% for correolide. " 08/06/2004 - "In adult male Sprague Dawley rats, constrictions to hypoxia, the Kv blocker 4-aminopyridine (4-AP), and correolide, a Kv1.x channel inhibitor, were endothelium-independent and greater in resistance versus conduit PAs. "

Related Drugs and Biologics

1.	4-Aminopyridine (4 Aminopyridine)
2.	5-(4-phenylbutoxy)psoralen