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OT 7100

structure in first source

Also Known As:

5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo(1,5-a)pyrimidine; OT-7100; OT7100

Networked: 3 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - OT 7100: 3
  - Pyrimidines: 510
    - OT 7100: 3

Experts

1.	Iwamoto, T: 2 articles (11/2001 - 11/2001)
2.	Miki, S: 2 articles (11/2001 - 11/2001)
3.	Sato, S: 2 articles (11/2001 - 11/2001)
4.	Yasuda, T: 2 articles (11/2001 - 11/2001)
5.	Yoshinaga, N: 2 articles (11/2001 - 11/2001)
6.	Noguchi, K: 1 article (11/2001)
7.	Okamoto, K: 1 article (11/2001)
8.	Senba, E: 1 article (11/2001)

Related Diseases

1.	Hyperalgesia 11/01/2001 - "These finding suggest that OT-7100 inhibits hyperalgesia in these animal models possibly by enhancing adenosinergic neurotransmission in the dorsal horn, although we still lack direct evidence for it." 01/01/1999 - "Single oral doses of 3 and 10 mg/kg OT-7100 were effective on the hyperalgesia induced by yeast. " 11/02/2001 - "To further characterize this compound, the present study examined the effects of OT-7100 on mechanical hyperalgesia and motor nerve conduction velocity in streptozotocin-induced diabetic rats. " 11/01/2001 - "A novel analgesic compound OT-7100 attenuates nociceptive responses in animal models of inflammatory and neuropathic hyperalgesia: a possible involvement of adenosinergic anti-nociception." 01/01/1999 - "These results suggest that OT-7100 is a new type of analgesic with the effect of normalizing the nociceptive threshold in peripheral neuropathic hyperalgesia."
2.	Peripheral Nerve Injuries 11/02/2001 - "These results suggest that OT-7100 alleviates hyperalgesia in a diabetic neuropathy model in a different manner from gabapentin or aldose reductase inhibitor and may be a new treatment for the pain associated with peripheral nerve injury."
3.	Pain (Aches) 11/02/2001 - "These results suggest that OT-7100 alleviates hyperalgesia in a diabetic neuropathy model in a different manner from gabapentin or aldose reductase inhibitor and may be a new treatment for the pain associated with peripheral nerve injury."
4.	Diabetic Neuropathies (Diabetic Neuropathy) 11/02/2001 - "Antinociceptive effect of the novel compound OT-7100 in a diabetic neuropathy model." 11/02/2001 - "These results suggest that OT-7100 alleviates hyperalgesia in a diabetic neuropathy model in a different manner from gabapentin or aldose reductase inhibitor and may be a new treatment for the pain associated with peripheral nerve injury."
5.	Neuralgia (Stump Neuralgia) 01/01/1999 - "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain. "

Related Drugs and Biologics

1.	Substance P
2.	Aldehyde Reductase (Aldose Reductase)
3.	Adenosine (Adenocard)
4.	Gabapentin (Neurontin)
5.	1,3-dipropyl-8-cyclopentylxanthine
6.	Streptozocin (Streptozotocin)
7.	Analgesics (Analgesic Drugs)
8.	Dinoprostone (PGE2)
9.	Indomethacin (Indometacin)
10.	pyrimidine