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negative elongation factor

a multisubunit complex; cooperates with DRB sensitivity-inducing factor (DSIF) to repress RNA polymerase II transcription elongation, do not confuse with NELF protein - Nasal Embryonic LHRH Factor
Also Known As:
Anon-66Da protein, Drosophila; COBRA1 protein, human; NELF-B protein, Drosophila; NELF-B protein, human; NELF-C protein, human; NELF-D protein, Drosophila; NELF-D protein, human; NELF-E protein, human; Nelf-E protein, Drosophila; RDBP protein, human; Radin blood group protein, human; TH1 protein, human; TH1-like (Drosophila) protein, human; TH1L protein, human; cofactor of BRCA1 protein, human; major histocompatibility complex protein RD, human; negative elongation factor (NELF); negative elongation factor A; negative elongation factor B; negative elongation factor B, human; negative elongation factor C; negative elongation factor D; negative elongation factor E; negative elongation factor E protein, Drosophila; negative elongation factor E, human; negative elongation factor NELF; negative elongation factor complex; negative elongation factor proteins C and D, human; trihydrophobin 1 protein, human
Networked: 21 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Handa, Hiroshi: 2 articles (06/2009 - 05/2007)
2. Narita, Takashi: 2 articles (06/2009 - 05/2007)
3. Yamaguchi, Yuki: 2 articles (06/2009 - 05/2007)
4. Yung, Tetsu M C: 2 articles (06/2009 - 05/2007)
5. Chen, Chelsey: 1 article (01/2022)
6. Chiang, Huai-Chin: 1 article (01/2022)
7. Cole, Robert N: 1 article (01/2022)
8. Hu, Yanfen: 1 article (01/2022)
9. Li, Rong: 1 article (01/2022)
10. Lu, Haiquan: 1 article (01/2022)

Related Diseases

1. Breast Neoplasms (Breast Cancer)
2. Neoplasms (Cancer)
3. Nervous System Diseases (Neurological Disorders)
4. Leukemia
05/01/2010 - "We benchmarked MAPLE with a number of human protein complexes involved in transcription, including the RNA polymerase II-associated factor, negative elongation factor, positive transcription elongation factor b, SWI/SNF, and mixed lineage leukemia complexes. "
01/01/2019 - "Abbreviations: CDK: Cyclin-dependent kinase; Pol II: RNA Polymerase II; PIC: Pre-initiation Complex; TFIIH: Transcription Factor-II H; snoRNA: small nucleolar RNA; CycT: CyclinT1/T2; P-TEFb: Positive Transcription Elongation Factor Complex; snRNP: small nuclear ribonucleo-protein; HEXIM: Hexamethylene Bis-acetamide-inducible Protein 1/2; LARP7: La-related Protein 7; MePCE: Methylphosphate Capping Enzyme; HIV: human immunodeficiency virus; TAT: trans-activator of transcription; TAR: Trans-activation response element; Hsp70: Heat Shock Protein 70; Hsp90/Cdc37: Hsp90- Hsp90 co-chaperone Cdc37; DSIF: DRB Sensitivity Inducing Factor; NELF: Negative Elongation Factor; CPSF: cleavage and polyadenylation-specific factor; CSTF: cleavage-stimulatory factor; eRNA: enhancer RNA; BRD4: Bromodomain-containing protein 4; JMJD6: Jumonji C-domain-containing protein 6; SEC: Super Elongation Complex; ELL: eleven-nineteen Lys-rich leukemia; ENL: eleven-nineteen leukemia; MLL: mixed lineage leukemia; BEC: BRD4-containing Elongation Complex; SEC-L2/L3: SEC-like complexes; KAP1: Kruppel-associated box-protein 1; KEC: KAP1-7SK Elongation Complex; DRB: Dichloro-1-ß-D-Ribofuranosylbenzimidazole; H2Bub1: H2B mono-ubiquitination; KM: KM05382; PP1: Protein Phosphatase 1; CDK9i: CDK9 inhibitor; SHAPE: Selective 2'-hydroxyl acylation analyzed by primer extension; TE: Typical enhancer; SE : Super enhancer."
5. AIDS-Related Complex (ARC)

Related Drugs and Biologics

1. RNA Polymerase II (RNA Polymerase B)
2. Estrogens (Estrogen)
3. Trefoil Factor-1
4. Proteins (Proteins, Gene)
5. DNA (Deoxyribonucleic Acid)
6. Positive Transcriptional Elongation Factor B
7. Peptide Elongation Factors (Elongation Factor)
8. Protein Phosphatase 1
9. Forkhead Transcription Factors (Forkhead Box Proteins)
10. Transcription Factor TFIIH