interleukin-18 binding protein

purified from the sera of mice with endotoxin shock using ligand affinity chromatography

Also Known As:

IL-18 binding proteins; IL-18BP protein, human; IL-18BP protein, mouse; IL18BP protein, human; Il18bp protein, mouse; Il18bp protein, rat; MC54L protein, mouse; interleukin 18 binding protein, human; interleukin 18 binding protein, mouse; interleukin 18 binding protein, rat

Networked: 40 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Novick, D: 4 articles (01/2009 - 12/2001)
2.	Rubinstein, M: 4 articles (01/2009 - 12/2001)
3.	Dinarello, Charles A: 4 articles (11/2008 - 11/2002)
4.	Fujita, Takayuki: 3 articles (01/2015 - 06/2011)
5.	Fuke, Yoshinobu: 3 articles (01/2015 - 06/2011)
6.	Matsumoto, Koichi: 3 articles (01/2015 - 06/2011)
7.	Shimizu, Chie: 3 articles (01/2015 - 06/2011)
8.	Soma, Masayoshi: 3 articles (01/2015 - 06/2011)
9.	Dinarello, C A: 3 articles (01/2009 - 08/2002)
10.	Novick, Daniela: 3 articles (06/2004 - 11/2002)

Related Diseases

1.	Sepsis (Septicemia) 08/01/2003 - "In this study, mice at low risk of death due to sepsis had decreased survival when treated with interleukin-18 binding protein. " 08/01/2003 - "Inflammatory status in sepsis alters efficacy of interleukin-18 binding protein therapy." 08/01/2003 - "Treatment with interleukin-18 binding protein decreased inflammation as determined by lower concentrations of plasma interleukin-6 obtained 48 hrs after the onset of sepsis. " 08/01/2003 - "We sought to determine the role of interleukin-18 in sepsis by blocking its biological activity with the interleukin-18 binding protein in the murine model of sepsis induced by cecal ligation and puncture. " 08/01/2003 - "Mice were subjected to cecal ligation and puncture and, on the basis of the plasma concentration of interleukin-6, were randomized to receive either interleukin-18 binding protein or vehicle approximately 8 hrs after the onset of sepsis. "
2.	Ischemia 01/01/2016 - "In the current study, we aimed to investigate whether interleukin-18 binding protein (IL-18BP) pretreatment has a protective effect against possible kidney injury following liver ischemia-reperfusion (IR) achieved by Pringle maneuver in an experimental rat model. " 01/01/2016 - "In the current study, we aimed to investigate whether interleukin-18 binding protein (IL-18BP) pretreatment has a protective effect against possible kidney injury-mediated liver ischemia-reperfusion (IR) achieved by Pringle maneuver in an experimental rat model. " 01/01/2016 - "Interleukin-18 Binding Protein Pretreatment Attenuates Kidney Injury Induced by Hepatic Ischemia Reperfusion." 01/01/2016 - "Antioxidant, Antiapoptotic and Inflammatory Effects of Interleukin-18 Binding Protein on Kidney Damage Induced by Hepatic Ischemia Reperfusion."
3.	Rheumatoid Arthritis 11/01/2023 - "Interleukin-18 binding protein regulates the apoptosis and necroptosis of fibroblast-like synoviocytes and chondrocytes in rheumatoid arthritis." 06/01/2004 - "Regulation of interleukin-18 binding protein production by blood and synovial cells from patients with rheumatoid arthritis." 06/01/2004 - "To study the regulation of interleukin-18 binding protein (IL-18BP) production by rheumatoid arthritis (RA) or control peripheral blood mononuclear cells (PBMCs) and by RA synovial tissue cells, and to compare the levels of IL-18BP messenger RNA (mRNA) expression in whole blood from RA patients and controls. " 11/01/2011 - "To examine the role of interferon regulatory factor 1 (IRF-1) in tumor necrosis factor α (TNFα)-induced interleukin-18 binding protein a (IL-18BPa) expression in rheumatoid arthritis synovial fibroblasts (RASFs). " 03/01/2010 - "Blocking ERK-1/2 reduces tumor necrosis factor alpha-induced interleukin-18 bioactivity in rheumatoid arthritis synovial fibroblasts by induction of interleukin-18 binding protein A."
4.	Inflammation (Inflammations) 08/01/2023 - "Excessive production and release of IL-18 disrupt the balance between IL-18 and IL-18 binding proteins in certain inflammatory diseases, leading to the occurrence of pathological inflammation. " 09/01/2007 - "Local concentrations of neutralizing IL-18 binding proteins (IL-18 bp) may counteract biological functions of mature IL-18 in mucosal inflammation. " 08/01/2003 - "Treatment with interleukin-18 binding protein decreased inflammation as determined by lower concentrations of plasma interleukin-6 obtained 48 hrs after the onset of sepsis. " 01/01/2022 - "For example, we observed upregulation of inflammation-inhibiting genes including NFKB inhibitor alpha (NFKBIA; fold-change (FC), adjusted P value: FC = 1.70, P = 0.007) and interleukin-18 binding protein (IL18BP: FC = 2.2, adjusted P = 0.02); and downregulation of proinflammatory genes including interleukin 7 receptor (IL7R: FC = -1.9, adjusted P = 0.02) and interleukin 1 receptor like 1 (IL1RL1: FC = -13.0, adjusted P = 0.02). "
5.	Non-alcoholic Fatty Liver Disease 01/01/2010 - "Through the chemotactic and proinflammatory effects, interleukin-18 may play a role in the pathogenesis of non-alcoholic fatty liver disease in Chinese patients, and it is reasonable to take into account interleukin-18 binding protein when evaluating the effect of interleukin-18." 01/01/2010 - "Patients with non-alcoholic fatty liver disease had significantly higher interleukin-18 (340.10 +/- 43.13pg/mL) and interleukin-18/ interleukin-18 binding protein ratio (1.31 +/- 0.12) compared with control group. " 01/01/2010 - "A total of 46 non-alcoholic fatty liver disease patients and 46 age- and sex-matched control subjects were enrolled to compare the clinical and laboratory characteristics and plasma levels of interleukin-18, interleukin-18 binding protein, and interleukin-18/interleukin-18 binding protein ratio. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Interleukin-18 (Interleukin 18)
3.	Cytokines
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Interferon-gamma (Interferon, gamma)
6.	Interferon Regulatory Factor-1 (Interferon Regulatory Factor 1)
7.	Interferon Regulatory Factors
8.	Intercellular Signaling Peptides and Proteins (Growth Factors)
9.	Interleukin-7 Receptors (Interleukin 7 Receptor)
10.	Interleukin-1 Receptors (Interleukin 1 Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Percutaneous Coronary Intervention
3.	Punctures
4.	Ligation
5.	Injections