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LY 389795

a group II metabotropic glutamate receptor agonist; structure in first source

Also Known As:

2-thia-4-aminobicyclo(3.1.0)hexane-4,6-dicarboxylic acid; LY-389795; LY389795

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - LY 389795: 3
Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - LY 389795: 3

Experts

1.	Eberle, Elizabeth Lutz: 1 article (01/2005)
2.	Jones, Carrie K: 1 article (01/2005)
3.	Monn, James A: 1 article (01/2005)
4.	Peters, Stephen C: 1 article (01/2005)
5.	Shannon, Harlan E: 1 article (01/2005)
6.	Iyengar, Smriti: 1 article (09/2002)
7.	Kalra, Anshu B: 1 article (09/2002)
8.	Simmons, Rosa Maria A: 1 article (09/2002)
9.	Webster, Amy A: 1 article (09/2002)
10.	Beart, P M: 1 article (07/2001)

Related Diseases

1.	Hyperalgesia 01/01/2005 - "Both LY379268 and LY389795 produced a dose-related reversal of carrageenan-induced thermal hyperalgesia and capsaicin-induced mechanical allodynia, but had no effect on carrageenan-induced mechanical allodynia. " 01/01/2005 - "In the present study, the effects of the selective group II metabotropic glutamate receptor agonists LY379268 and LY389795 were evaluated in the formalin test, carrageenan-induced thermal hyperalgesia and mechanical allodynia, and capsaicin-induced mechanical allodynia in rats. "
2.	Pain (Aches) 01/01/2005 - "Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing." 09/01/2002 - "LY354740, LY379268 and LY389795 attenuated late-phase paw-licking pain behavior in a dose-dependent manner in the formalin model of persistent pain. "
3.	Seizures (Absence Seizure) 07/01/2001 - "Sound-induced clonic seizures in DBA/2 mice were transiently inhibited by both agonists intracerebroventricularly (i.c.v.), LY379268 ED(50)=0.08 [0.02-0.33]nmol and LY389795 ED(50)=0.82 [0.27-3.24]nmol or intraperitoneally (i.p.), LY379268 ED(50)=2.9 [0.9-9.6]mg/kg and LY389795 ED(50)=3.4 [1.0-11.7]mg/kg. Both mGlu(2/3) agonists inhibited seizures induced by the group I mGlu receptor agonist (R,S)-3,5-dihydroxyphenylglycine (DHPG), where LY379268, i.c.v. ED(50)=0.3 [0.02-5.0]pmol and LY389795, i.c.v. ED(50)=0.03 [0.05-0.19]nmol. "

Related Drugs and Biologics

1.	LY 379268
2.	Formaldehyde (Formol)
3.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
4.	Carrageenan
5.	Capsaicin (Zostrix)
6.	Analgesics (Analgesic Drugs)
7.	eglumetad
8.	3,4-dihydroxyphenylglycol