BIO 1211

integrin alpha4beta1 inhibitor; structure in first source

Also Known As:

BIO-1211; N-((4-((((2-methylphenyl)amino)carbonyl)amino)phenyl)acetyl)-leucyl-aspartyl-valyl-proline; L-Proline, N-(2-(4-((((2-methylphenyl)amino)carbonyl)amino)phenyl)acetyl)-L-leucyl-L-alpha-aspartyl-L-valyl-

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - BIO 1211: 5

Experts

1.	Chen, Ji-qiang: 2 articles (01/2008 - 01/2003)
2.	Xie, Qiang-min: 2 articles (01/2008 - 01/2003)
3.	Abdollahi, Mohammad: 1 article (01/2015)
4.	Ganjali, Zohre: 1 article (01/2015)
5.	Javan, Mohammad Reza: 1 article (01/2015)
6.	Khalseh, Roghayeh: 1 article (01/2015)
7.	Khani, Masood: 1 article (01/2015)
8.	Ramroodi, Nourollah: 1 article (01/2015)
9.	Ravan, Hadi: 1 article (01/2015)
10.	Sanadgol, Ehsan: 1 article (01/2015)

Related Diseases

1.	Asthma (Bronchial Asthma) 05/01/2000 - "Merck has begun phase II trials with the lead compound, BIO-1211, for asthma, Biogen is still conducting preclinical research for its designated indications [317648,319225]. "
2.	Respiratory Sounds (Crackle) 01/01/2008 - "The effect of BIO-1211 on wheezing was determined after inhalation of histamine and acetylcholine in guinea pigs. "
3.	Respiratory Hypersensitivity 03/11/1999 - "Pretreatment of allergic sheep with a 3-mg nebulized dose of BIO-1211 inhibited early and late airway responses following antigen challenge and prevented development of nonspecific airway hyperresponsiveness to carbachol. "
4.	Multiple Sclerosis 01/01/2015 - "Prophylactic Effect of BIO-1211 Small-Molecule Antagonist of VLA-4 in the EAE Mouse Model of Multiple Sclerosis." 01/01/2015 - "In this regard small-molecule antagonists can have a wide range of impacts, so in this research, we examine the prophylactic effects of BIO-1211 [Very Late Antigen-4 (VLA4) blocker], in experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis in comparison with commercial available medicine, Natalizumab (NTZ)]. "
5.	Inflammation (Inflammations) 01/01/2003 - "BIO-1211 inhibits eosinophil chemotaxis and recruitment, alleviates local inflammation, and may represent a new type of drug for allergic diseases."

Related Drugs and Biologics

1.	Integrin alpha4beta1 (VLA-4)
2.	Histamine (Histamine Dihydrochloride)
3.	Carbachol (Carbastat)
4.	Antigens
5.	Acetylcholine (Acetylcholine Chloride)
6.	Natalizumab (Tysabri)
7.	nitazoxanide (NTZ)