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7- (hydroxyimino)cyclopropan(b)chromen- 1a- carbxoylic acid ethyl ester

Also Known As:

CPCCOEt

Networked: 11 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester: 11
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester: 11

Experts

1.	Neugebauer, Volker: 3 articles (05/2011 - 01/2004)
2.	Ahn, Dong K: 3 articles (12/2006 - 11/2005)
3.	Choi, Hyo S: 3 articles (12/2006 - 11/2005)
4.	Jung, Chang Y: 3 articles (12/2006 - 11/2005)
5.	Lim, Eun J: 2 articles (12/2006 - 11/2005)
6.	Youn, Dong H: 2 articles (12/2006 - 11/2005)
7.	Bae, Yong C: 2 articles (10/2006 - 11/2005)
8.	Dalley, Carrie Bowman: 1 article (10/2018)
9.	Wolfe, Barry B: 1 article (10/2018)
10.	Wroblewska, Barbara: 1 article (10/2018)

Related Diseases

1.	Arthritis (Polyarthritis) 05/19/2011 - "A selective mGluR1 antagonist (CPCCOEt) had no effect on enhanced synaptic transmission in slices from H1a-BLA mice with arthritis but inhibited transmission in wild-type mice with arthritis as in our previous studies in rats. " 01/01/2005 - "Vocalizations were recorded in the same animals before arthritis, 6 h after arthritis induction and during administration of antagonists selective for mGluR1 (CPCCOEt) and mGluR5 (MPEP) into the CeA through stereotaxically implanted microdialysis probes. " 01/01/2004 - "An mGluR1 antagonist (CPCCOEt) had no effect before arthritis (n = 12) but inhibited the responses of sensitized neurons in the arthritis pain state (n = 8). "
2.	Hypersensitivity (Allergy) 04/25/2007 - "Subsequent behavioral studies demonstrated that the group I mGluR agonist, R,S-3,5-dihydroxyphenylglycol (DHPG), significantly decreased the mechanical threshold to noxious stimulation of the masseter, and that the DHPG-induced mechanical hypersensitivity can be effectively prevented by pretreatment of the masseter with 2-methyl-6-(phenylethynyl)pyridine hydrochloride (MPEP), a selective mGluR 5 antagonist, but not by 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt), a selective mGluR 1 antagonist. "
3.	Hyperalgesia 10/01/2006 - "Intracisternal administration of CPCCOEt, a mGluR1 antagonist, or MPEP, a mGluR5 antagonist, reduced IL-1beta-induced mechanical allodynia and mirror-image mechanical allodynia. " 10/13/2004 - "Finally, intrathecal pretreatment of CPCCOEt, MPEP, and 2APB attenuates inflammatory hyperalgesia. " 12/06/2006 - "Pre-treatment with 7-(hydroxyimino) cyclopropa[b] chromen-1a-carboxylate ethyl ester (CPCCOEt) or 2-methyl-6-(phenylethynyl)-pyridine hydrochloride (MPEP), a mGluR1 or mGluR5 antagonist, blocked IL-1beta-induced mechanical allodynia and mirror-image mechanical allodynia produced by a subcutaneous injection of 10 pg of IL-1beta. " 11/01/2005 - "Subcutaneous administration of CPCCOEt or LY367385, an mGluR1 antagonist, or MPEP or SIB1893, an mGluR5 antagonist, 10 min prior to injection of IL-1beta abolished IL-1beta-induced mechanical allodynia. "
4.	Pain (Aches) 03/01/2009 - "Amygdaloid administration of DHPG increased and that of CPCCOEt decreased affective pain-related behavior in nerve-injured animals. " 01/01/2004 - "An mGluR1 antagonist (CPCCOEt) had no effect before arthritis (n = 12) but inhibited the responses of sensitized neurons in the arthritis pain state (n = 8). "
5.	Melanoma (Melanoma, Malignant) 06/01/2007 - "The non-competitive metabotropic glutamate receptor-1 antagonist CPCCOEt inhibits the in vitro growth of human melanoma." 06/01/2007 - "Here we report that a selective, non-competitive metabotropic glutamate receptor-1 antagonist, CPCCOEt (7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester), significantly inhibited the proliferation and modified the morphology of two human melanoma cell lines. "

Related Drugs and Biologics

1.	metabotropic glutamate receptor type 1
2.	Esters
3.	3,4-dihydroxyphenylglycol
4.	6-methyl-2-(phenylethynyl)pyridine
5.	Glutamic Acid (Glutamate)
6.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
7.	Phosphotransferases (Kinase)
8.	Freund's Adjuvant
9.	Carboxylic Acids
10.	(3,4- dihydro- 2H- pyrano(2,3)b- quinolin- 7- yl)- (cis- 4- methoxycyclohexyl) methanone

Related Therapies and Procedures

1.	Subcutaneous Injections