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glutathione S-transferase M1

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member of the mu family of cytosolic glutathione transferases; involved in carcinogen metabolism and have been shown to influence the risk a variety of solid tumors in adults

Also Known As:

GSTM1 protein, human; Gstm1 protein, mouse; Gstm1 protein, rat; glutathione S-transferase M1, human; glutathione S-transferase, mu 1 protein, mouse; glutathione S-transferase, mu 1 protein, rat

Networked: 405 relevant articles (3 outcomes, 76 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Transferases: 4296
    - Alkyl and Aryl Transferases: 2
      - Glutathione Transferase: 2935
        glutathione S-transferase M1: 405

Experts

1.	Hirvonen, Ari: 5 articles (01/2006 - 03/2002)
2.	Zhang, Yi: 4 articles (01/2015 - 01/2013)
3.	Saadat, Mostafa: 4 articles (11/2014 - 07/2004)
4.	London, Stephanie J: 4 articles (01/2009 - 08/2002)
5.	Kang, Daehee: 4 articles (11/2006 - 03/2002)
6.	Tsai, Fuu-Jen: 4 articles (11/2005 - 07/2004)
7.	Garte, Seymour: 4 articles (09/2005 - 05/2003)
8.	Tamer, Lülüfer: 4 articles (07/2005 - 09/2004)
9.	Ateş, Nurcan Aras: 4 articles (07/2005 - 09/2004)
10.	Kalina, Ivan: 4 articles (02/2004 - 07/2002)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2013 - "Many studies have investigated associations between the glutathione S-transferase M1 (GSTM1) null polymorphism and risk of prostate cancer, but the impact of GSTM1 in people who live in Asian countries is still unclear owing to inconsistencies across results. " 01/01/2013 - "Genetic polymorphisms of glutathione S-transferase M1 and prostate cancer risk in Asians: a meta-analysis of 18 studies." 10/01/2010 - "Polymorphisms of glutathione-S-transferase M1 and T1 and prostate cancer risk in a Tunisian population." 01/01/2009 - "Polymorphisms of glutathione-S-transferase M1, T1, P1 and the risk of prostate cancer: a case-control study." 10/01/2006 - "Polymorphisms in the glutathione S-transferase M1, T1, and P1 genes and prostate cancer prognosis."
2.	Parkinson Disease (Parkinson's Disease) 01/30/2003 - "Glutathione S-transferase M1, T1, and P1 polymorphisms and Parkinson's disease." 04/01/2004 - "The present study was conducted to examine the interaction between cytochrome p450 2D6: CYP2D6 (phase I) poor metabolizer (PM) and glutathione S-transferase M1: GSTM1 (phase II) null genotypes, among 103 unrelated French Parkinson's disease (PD) patients. " 03/15/2014 - "The Glutathione S-transferase M1 (GSTM1) and Glutathione S-transferase T1 (GSTT1) genes have been studied extensively as potential candidate genes for the risk of Parkinson's disease (PD). " 03/15/2014 - "Association between Glutathione S-transferase M1/Glutathione S-transferase T1 polymorphisms and Parkinson's disease: a meta-analysis." 02/01/2004 - "A number of other candidate gene polymorphisms including cytochrome P450 2D6, N-acetyltransferase 2, monoamine oxidase-B and glutathione-s-transferase M1 are implicated in sporadic and familial cases and may also play a minor role in the aetiology of Parkinson's disease."
3.	Open-Angle Glaucoma (Glaucoma, Open Angle) 04/01/2005 - "May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?" 04/01/2007 - "Glutathione S transferase M1 and T1 genetic polymorphisms are related to the risk of primary open-angle glaucoma: a study in a Turkish population." 11/01/2000 - "Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians."
4.	Neoplasms (Cancer) 03/01/2014 - "Glutathione S-transferase M1 (GSTM1) polymorphism has been proven to be associated with risks of several cancers. " 01/01/2013 - "Association of the glutathione s-transferase m1, t1 polymorphisms with cancer: evidence from a meta-analysis." 12/01/2011 - "The glutathione S-transferase M1 null polymorphism was associated with increased risk of low-grade intra-epithelial lesions (OR 1.37, 95% CI 1.05-1.77), but no increased risk of high-grade intra-epithelial lesions (OR 1.29, 95% CI 0.87-1.8) or invasive cervical cancer (OR 1.20, 95% CI 0.99-1.46). " 06/01/2011 - "Glutathione S-transferase M1 (GSTM1) might be involved in inactivation of procarcinogens that contribute to the genesis and progression of cancers. " 01/01/2011 - "Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: a meta-analysis."
5.	Hepatocellular Carcinoma (Hepatoma) 01/01/2006 - "Glutathione S-transferase M1 and T1 genetic polymorphisms are not related to the risk of hepatocellular carcinoma: a study in the Spanish population." 06/01/1999 - "To Study whether the mutation of deletion for glutathione S-transferase M1 (GSTM1) gene occurred during the development of hepatocellular carcinoma (HCC). " 08/01/2014 - "Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) have been involved in the risk of hepatocellular carcinoma (HCC). " 08/01/2014 - "Interactive effect of glutathione S-transferase M1 and T1 polymorphisms on hepatocellular carcinoma." 01/01/2014 - "Glutathione S-transferase M1 (GSTM1) have been reported to be associated with hepatocellular carcinoma. "

Related Drugs and Biologics

1.	Cytochrome P-450 CYP1A1 (CYP1A1)
2.	NAD (NADH)
3.	DNA (Deoxyribonucleic Acid)
4.	Oxidoreductases
5.	Carcinogens
6.	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)
7.	Leptin
8.	Somatomedins (Somatomedin)
9.	Gonadal Steroid Hormones (Sex Hormones)
10.	Androgen Receptors (Androgen Receptor)

Related Therapies and Procedures

1.	Radiotherapy
2.	Drug Therapy (Chemotherapy)