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RFT5(scFv)-ETA'

a recombinant single-chain immunotoxin with specific cytotoxicity toward CD25(+) Hodgkin-derived cell lines; amino acid sequence in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Immunoglobulin Fragments: 976
        Immunoglobulin Fab Fragments: 769
        Immunoglobulin Variable Region: 208
        Single-Chain Antibodies: 852
        RFT5(scFv)-ETA': 1
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        Single-Chain Antibodies: 852
        RFT5(scFv)-ETA': 1
        Immunoglobulin Fragments: 976
        Immunoglobulin Fab Fragments: 769
        Immunoglobulin Variable Region: 208
        Single-Chain Antibodies: 852
        RFT5(scFv)-ETA': 1
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Immunoglobulin Fragments: 976
        Immunoglobulin Fab Fragments: 769
        Immunoglobulin Variable Region: 208
        Single-Chain Antibodies: 852
        RFT5(scFv)-ETA': 1
- Peptides: 82426
  - Peptide Fragments: 373
    - Immunoglobulin Fragments: 976
      - Immunoglobulin Fab Fragments: 769
        Immunoglobulin Variable Region: 208
        Single-Chain Antibodies: 852
        RFT5(scFv)-ETA': 1

Experts

1.	Barth, S: 1 article (06/2000)
2.	Diehl, V: 1 article (06/2000)
3.	Engert, A: 1 article (06/2000)
4.	Huhn, M: 1 article (06/2000)
5.	Lorenzen, J: 1 article (06/2000)
6.	Matthey, B: 1 article (06/2000)
7.	Schinköthe, T: 1 article (06/2000)
8.	Schnell, R: 1 article (06/2000)
9.	Tawadros, S: 1 article (06/2000)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2000 - "Our findings, concerning potent anti-tumor effects of a recombinant anti-CD25 immunotoxin against disseminated Hodgkin's lymphoma in SCID mice reported here demonstrate that RFT5(scFv)-ETA' might be suitable for further evaluation against Hodgkin's lymphoma in humans."
2.	Hodgkin Disease (Hodgkin's Disease) 06/01/2000 - "RFT5(scFv)-ETA' was subsequently used for the treatment of disseminated human Hodgkin's lymphoma in a SCID-mouse model. " 06/01/2000 - "Recombinant anti-CD25 immunotoxin RFT5(SCFV)-ETA' demonstrates successful elimination of disseminated human Hodgkin lymphoma in SCID mice." 06/01/2000 - "Our findings, concerning potent anti-tumor effects of a recombinant anti-CD25 immunotoxin against disseminated Hodgkin's lymphoma in SCID mice reported here demonstrate that RFT5(scFv)-ETA' might be suitable for further evaluation against Hodgkin's lymphoma in humans."

Related Drugs and Biologics

1.	Immunotoxins (Immunotoxin)