heregulin alpha

03/20/2003 - "Indeed, immediately following a mechanical injury, heregulin-alpha activates erbB2 in cells at the edge of the wound, and this process hastens restoration of epithelial integrity. "
12/01/2002 - "HER-4 - another receptor for heregulin-alpha - is weakly present in occasional cells near the edge of the wound. "
09/01/2002 - "In this study, we examined the effects of EGF, TGFalpha, amphiregulin and heregulin-alpha (HRGalpha) on proliferation, wound closure, and the expression of their receptors c-erbB1-c-erbB4 in primary cultures of human urothelial cells in vitro. "

01/01/1999 - "In this study, we report differential expression of P185erbB-2, P160erbB-3 and P180erbB-4, and their ligand heregulin alpha, in normal bronchial epithelial, and non-small cell lung carcinoma (NSCLC) cell lines. "

12/01/2002 - "Heregulin-alpha has already been shown to be the motility factor leading to migration of HER-2/neu-overexpressing breast cancer cells. "
04/19/2000 - "Binding of heregulin-alpha to the receptor complex on Paget cells results in the chemotaxis of these breast cancer cells, which eventually migrate into the overlying nipple epidermis."
06/01/1993 - "Expression of amphiregulin, cripto-1, and heregulin-alpha in human breast-cancer cells."
03/01/2005 - "ERRP and trastuzumab, but not cetuximab, attenuated heregulin-alpha-induced activation of colon and breast cancer cells that expressed high levels of HER-2. "
05/22/1992 - "A 45-kilodalton protein heregulin-alpha (HRG-alpha) that specifically induced phosphorylation of p185erbB2 was purified from the conditioned medium of a human breast tumor cell line. "

01/01/1999 - "These data suggest that constitutive activation of erbB-2, erbB-3 and erbB-4 receptors could be induced by heregulin alpha via an autocrine loop mechanism, and that the active forms of erbB-4 may cooperate with the other members of the EGF-receptor family in human lung carcinogenesis."
12/01/2002 - "The role of amphiregulin as a growth factor and of heregulin-alpha as a motility factor for keratinocytes in epidermal and mucosal wound healing parallels their motility and growth induction in carcinogenesis."

01/01/1999 - "Heregulin alpha is expressed at intermediate levels in the normal and cancer cell lines studied. "
08/01/1997 - "Expression of the ligand heregulin-alpha was detected in 31% of tumors. "