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SB 271046

5-HT(6) receptor antagonist; structure in first source

Also Known As:

5-chloro-N-(4-methoxy-3-piperazin-1-ylphenyl)-3-methyl-2-benzothiophenesulfonamide; SB-271046

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - SB 271046: 7
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - SB 271046: 7
  - Thiophenes: 257
    - SB 271046: 7
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - SB 271046: 7

Experts

1.	Picazo Picazo, Ofir: 1 article (01/2022)
2.	Roldán Roldán, Gabriel: 1 article (01/2022)
3.	Suárez-Santiago, José Eduardo: 1 article (01/2022)
4.	Huang, Huapin: 1 article (03/2019)
5.	Huang, Mingzhu: 1 article (03/2019)
6.	Lin, Rong: 1 article (03/2019)
7.	Lin, Wanhui: 1 article (03/2019)
8.	Liu, Changyun: 1 article (03/2019)
9.	Ma, Ying: 1 article (03/2019)
10.	Wen, Yuxing: 1 article (03/2019)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 04/01/2002 - "Effects of the 5-HT(6) receptor antagonist, SB-271046, in animal models for schizophrenia." 04/01/2002 - "We studied the effect of SB-271046 [5-chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide], a specific 5-HT(6) receptor antagonist, in three models for the positive symptoms of schizophrenia---D-amphetamine-induced hyperactivity, and D-amphetamine- or phencyclidine (PCP)-disrupted prepulse inhibition (PPI). " 10/01/2008 - "These data suggest a potential therapeutic role of 5-HT6 receptor antagonists such as SB-271046, alone or in combination with galanthamine, in the treatment of cognitive dysfunction, such as those seen in Alzheimer's disease and schizophrenia."
2.	Cognitive Dysfunction 10/01/2008 - "These data suggest a potential therapeutic role of 5-HT6 receptor antagonists such as SB-271046, alone or in combination with galanthamine, in the treatment of cognitive dysfunction, such as those seen in Alzheimer's disease and schizophrenia."
3.	Seizures (Absence Seizure) 03/01/2019 - "Results showed that frequency of spontaneous recurrent seizures (SRSs) was significantly decreased in pilocarpine-induced epileptic rats that treated with SB-271046. "
4.	Pain (Aches) 08/13/2007 - "These data provide the first evidence for 5-HT(6) receptor-mediated regulation of nociception and hypothalamo-pituitary-adrenal axis activity in a model of persistent pain although effects on locomotor activity demand that the putative antinociceptive effect of SB-271046 be interpreted with some caution."
5.	Memory Disorders (Memory Loss) 01/01/2022 - "The acute administration of both 5-HT6 agents reversed the memory deficit and induced a decrease in anxiety, whereas SB-271046 administration produced a decrease in climbing behavior. "

Related Drugs and Biologics

1.	serotonin 6 receptor
2.	Scopolamine (Hyoscine)
3.	Pilocarpine (Ocusert)
4.	Phencyclidine (Angel Dust)
5.	Galantamine (Galanthamine)
6.	Dextroamphetamine (Dexedrine)