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2,2,3,3-tetramethylcyclopropane carboxamide

structure in first source

Also Known As:

TMCD

Networked: 6 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - 2,2,3,3-tetramethylcyclopropane carboxamide: 6
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclopropanes: 9
        2,2,3,3-tetramethylcyclopropane carboxamide: 6

Experts

1.	Bialer, Meir: 4 articles (10/2010 - 02/2002)
2.	Yagen, Boris: 4 articles (10/2010 - 02/2002)
3.	Finnell, Richard H: 3 articles (10/2010 - 02/2002)
4.	Sobol, Eyal: 2 articles (01/2007 - 12/2005)
5.	White, H Steve: 2 articles (01/2007 - 02/2002)
6.	Ammendola, Michele: 1 article (04/2017)
7.	Gadaleta, Claudia: 1 article (04/2017)
8.	Gadaleta, Cosmo Damiano: 1 article (04/2017)
9.	Kocak, Ibrahim Furkan: 1 article (04/2017)
10.	Luposella, Maria: 1 article (04/2017)

Related Diseases

1.	Neural Tube Defects (Exencephaly) 10/01/2010 - "Induction of neural tube defects (NTDs) by α-Cl-TMCD and α-F-TMCD was evaluated after intraperitoneal administration to a mouse strain highly susceptible to VPA-induced teratogenicity. " 01/01/2007 - "Teratogenicity studies performed in a SWV/Fnn-mouse model for VPA-induced-exencephaly showed that on the equimolar basis OM-TMCD possesses the same fetal toxicity and ability to induce NTDs as VPA, but since OM-TMCD is a much more potent anticonvulsant its activity/exencephaly formation ratio appears to be much more beneficial than that of VPA. " 01/01/2007 - "The structural considerations used in the design of OM-TMCD were aimed to enhance OM-TMCD anticonvulsant potency (compared to VPA) and to prevent VPA's two life-threatening side effects, i.e., induction of neural tube defects (NTDs) and hepatotoxicity. " 02/01/2002 - "The studies presented here represent our efforts to investigate the anticonvulsant activity of N-methyl-tetramethylcyclopropyl carboxamide (M-TMCD) and its metabolite tetramethylcyclopropyl carboxamide (TMCD) in various animal (rodent) models of human epilepsy, and to evaluate their ability to induce neural tube defects (NTDs) and neurotoxicity. "
2.	Epilepsy (Aura) 10/01/2010 - "This study aimed to comparatively evaluate the pharmacodynamics and pharmacokinetics of α-F-TMCD and α-Cl-TMCD in rodent models of epilepsy and for antiepileptic drug (AED)-induced teratogenicity. " 02/01/2002 - "The ability of M-TMCD and TMCD to block electrical-, chemical-, or sensory-induced seizures was examined in eight animal models of epilepsy. " 02/01/2002 - "The studies presented here represent our efforts to investigate the anticonvulsant activity of N-methyl-tetramethylcyclopropyl carboxamide (M-TMCD) and its metabolite tetramethylcyclopropyl carboxamide (TMCD) in various animal (rodent) models of human epilepsy, and to evaluate their ability to induce neural tube defects (NTDs) and neurotoxicity. "
3.	Pain (Aches) 10/01/2010 - "α-F-TMCD was active in the two pain models, and was found to be equipotent to gabapentin in the SNL model (ED(50) = 37 and 32 mg/kg, respectively). " 06/01/2010 - "The TMCD does not contain texts referring to information given to the patient, pain control, palliative care and management of the end of life as well as protection of medical data. " 10/01/2010 - "The ability of α-F-TMCD to reduce pain was evaluated in the rat spinal nerve ligation (SNL) model for neuropathic pain and in the formalin test. "
4.	Stomach Neoplasms (Stomach Cancer) 04/01/2017 - "Nevertheless, no data are available concerning the relationship among tryptase MC density (TMCD), endothelial cells (ECs) positive to PAR-2 microvascular density (PAR-2-MVD) and classical MVD (C-MVD) in gastric cancer (GC) angiogenesis. "
5.	Seizures (Absence Seizure) 02/01/2002 - "The ability of M-TMCD and TMCD to block electrical-, chemical-, or sensory-induced seizures was examined in eight animal models of epilepsy. " 02/01/2002 - "Unlike M-TMCD, TMCD was active only against Metrazol-induced seizures in mice and rats (ED50 values of 57 and 52 mg/kg, respectively). "

Related Drugs and Biologics

1.	Anticonvulsants (Antiepileptic Drugs)
2.	N-methyl 2,2,3,3-tetramethylcyclopropane carboxamide
3.	Tryptases (Tryptase)
4.	Pentylenetetrazole (Metrazol)
5.	Formaldehyde (Formol)
6.	Acids
7.	Gabapentin (Neurontin)

Related Therapies and Procedures

1.	Palliative Care (Palliative Therapy)
2.	Ligation