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cadmium-metallothionein complex

metallothionein which serves in a metal-sequestering mechanism

Also Known As:

CdMT complex

Networked: 5 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Metalloproteins: 164
    - Metallothionein: 1832
      - cadmium-metallothionein complex: 5

Experts

1.	Arreola-Mendoza, Laura: 1 article (07/2021)
2.	Barbier, Olivier Christophe: 1 article (07/2021)
3.	Jacobo-Estrada, Tania Libertad: 1 article (07/2021)
4.	Lee, Wing-Kee: 1 article (07/2021)
5.	Narváez-Morales, Juana: 1 article (07/2021)
6.	Ortega-Romero, Manolo Sibael: 1 article (07/2021)
7.	Thévenod, Frank: 1 article (07/2021)
8.	Zavala-Guevara, Itzel Pamela: 1 article (07/2021)

Related Diseases

1.	Acute Kidney Injury (Acute Renal Failure) 07/06/2021 - "In this study, we evaluated the uptake of labeled CdMT complex through 24p3R after acute kidney injury (AKI) induced by gentamicin (GM) administration that disrupts PT function. " 07/01/1998 - "We have shown that: (1) MT-transgenic and -null mice have altered tissue MT protein levels; (2) MT-transgenic and -null mice appear to be normal in other detoxifying systems examined, except for slight alterations in tissue Zn concentration; (3) MT does not appear to inhibit Cd absorption from the gastrointestinal tract, nor affect Cd tissue distribution; (4) MT reduces the elimination of Cd from liver; (5) MT protects against acute inorganic Cd-induced lethality and hepatotoxicity, and the mechanism of the protection appears to be due to its ability to sequester Cd in the cytosol, thus reducing the amount of Cd in critical organelles; (6) MT modulates Cd-induced expression of protooncogene(c-jin) and tumor suppress genes (p53) in mouse liver; (7) MT does not protect against CdMT-induced acute renal injury, and Zn-induced protection against CdMT-induced acute nephrotoxicity does not appear to be mediated through MT; (8) Chronic Cd administration produces renal injury inb MT-null mice, indicating that Cd-induced nephrotoxicity is not necessarily mediated through the CdMT complex; (9) MT protects against chronic CdC12 nephropathy, suggesting that intracellular MT is an important adaptive mechanism decreasing CdC12 nephrotoxicity, and that a single injection of CdMT may not be a good model to study chronic Cd nephropathy; (10) genetic background of mouse strains, rather than constitutive MT levels, is a more important determinant for Cd-induced acute testicular injury. "
2.	Neoplasms (Cancer) 07/01/1998 - "We have shown that: (1) MT-transgenic and -null mice have altered tissue MT protein levels; (2) MT-transgenic and -null mice appear to be normal in other detoxifying systems examined, except for slight alterations in tissue Zn concentration; (3) MT does not appear to inhibit Cd absorption from the gastrointestinal tract, nor affect Cd tissue distribution; (4) MT reduces the elimination of Cd from liver; (5) MT protects against acute inorganic Cd-induced lethality and hepatotoxicity, and the mechanism of the protection appears to be due to its ability to sequester Cd in the cytosol, thus reducing the amount of Cd in critical organelles; (6) MT modulates Cd-induced expression of protooncogene(c-jin) and tumor suppress genes (p53) in mouse liver; (7) MT does not protect against CdMT-induced acute renal injury, and Zn-induced protection against CdMT-induced acute nephrotoxicity does not appear to be mediated through MT; (8) Chronic Cd administration produces renal injury inb MT-null mice, indicating that Cd-induced nephrotoxicity is not necessarily mediated through the CdMT complex; (9) MT protects against chronic CdC12 nephropathy, suggesting that intracellular MT is an important adaptive mechanism decreasing CdC12 nephrotoxicity, and that a single injection of CdMT may not be a good model to study chronic Cd nephropathy; (10) genetic background of mouse strains, rather than constitutive MT levels, is a more important determinant for Cd-induced acute testicular injury. "
3.	Proteinuria 01/01/1987 - "Data from these studies indicate that renal proximal tubule cell uptake and degradation of the circulating CdMT complex produces both a marked proteinuria and calcuria. " 10/01/1983 - "Ultrastructural morphometry, X-ray microanalysis, and biochemical studies of the low-molecular-weight tubular proteinuria produced by injection of cadmium metallothionein (CdMT) showed a rapid proximal tubule cell lysosome uptake and degradation of the CdMT complex, which led to a subsequent decrease in the numerical density (Nv) and average diameter of lysosomes and to an increase in the Nv of apical pinocytolic vesicles with time. "
4.	Necrosis 04/01/1975 - "Mice are protected from cadmium-induced testicular necrosis by metallothionein, but in this experiment it was shown that cadmium-metallothionein complex injected into mice results in higher cadmium levels in renal cortex and more severe renal tubular cell injury than a comparable dose of cadmium chloride administered by the same route. "

Related Drugs and Biologics

1.	D-4-chloro-17 beta-hydroxy-3-oxo-17 alpha-methylandrosta-1,4-diene
2.	Proteins (Proteins, Gene)
3.	Gentamicins (Gentamicin)
4.	cadmium-binding protein
5.	Cadmium Chloride (Cadmium Dichloride)
6.	Metallothionein
7.	Cadmium