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7-(2-hydroxypropyl)guanine

constitutes the major adduct from alkylation of DNA by the genotoxic carcinogen, propylene oxide

Also Known As:

7-HPG

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        7-(2-hydroxypropyl)guanine: 1

Experts

1.	Faller, Thomas: 1 article (07/2003)
2.	Filser, Johannes G: 1 article (07/2003)
3.	Lee, Moung S: 1 article (07/2003)
4.	Ranasinghe, Asoka: 1 article (07/2003)
5.	Ríos-Blanco, Melva N: 1 article (07/2003)
6.	Swenberg, James A: 1 article (07/2003)

Related Diseases

1.	Carcinogenesis 07/01/2003 - "As PO-induced tumor formation was highly sublinear, occurring only at high vapor concentrations, whereas 7-HPG adducts were shown to be linearly dependent on airborne concentration, these results suggest that 7-HPG is not sufficient for PO nasal carcinogenesis and that other factors such as increased cell proliferation may be important in determining the tumor exposure response."
2.	Neoplasms (Cancer) 07/01/2003 - "As PO-induced tumor formation was highly sublinear, occurring only at high vapor concentrations, whereas 7-HPG adducts were shown to be linearly dependent on airborne concentration, these results suggest that 7-HPG is not sufficient for PO nasal carcinogenesis and that other factors such as increased cell proliferation may be important in determining the tumor exposure response."