PEO-PPO-PEO

a triblock copolymer; PE-6200 is EO5-PO31-EO5

Also Known As:

EO5-PO31-EO5; EO81-PO31-EO81; F68 polymer; PE 6200; PE-6200; PE6200; Tetronic 908; pluronic P65; poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide); poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)

Networked: 15 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gan, Yong: 3 articles (01/2020 - 08/2010)
2.	Zhang, Xinxin: 2 articles (01/2020 - 08/2010)
3.	Ebrahimi, Marzieh: 1 article (04/2021)
4.	Firouzi, Javad: 1 article (04/2021)
5.	Miller, Donald W: 1 article (04/2021)
6.	Norouzi, Mohammad: 1 article (04/2021)
7.	Sodeifi, Niloufar: 1 article (04/2021)
8.	Gupta, Jitendra: 1 article (01/2021)
9.	Gupta, Reena: 1 article (01/2021)
10.	Mishra, Manoj Kumar: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "Therefore, both PEO-PPO-PEO and PLGA nanoparticle formulations were effective in reducing cancer cell viability, while PLGA nanoparticles incorporating kaempferol had selective toxicity against cancer cells and normal cells. " 01/01/2021 - "Self-Assemble Amphiphilic PEO-PPO-PEO Tri-Block Co-Polymeric Methotrexate Nanomicelles to Combat MCF7 Cancer Cells." 01/01/2012 - "Both PEO-PPO-PEO and PLGA nanoparticle formulations had superior effects compared with kaempferol alone in reducing cancer cell viability." 01/01/2012 - "PEO-PPO-PEO nanoparticles incorporating kaempferol may be suitable as a cancer-targeting strategy, which could limit the effects of the nanoparticles on normal cells while retaining their potency against cancer cells. " 01/01/2012 - "On the other hand, PEO-PPO-PEO nanoparticles incorporating kaempferol were more effective inhibitors of cancer cells, but they also significantly reduced the viability of normal cells. "
2.	Hemolysis 07/01/2012 - "Relationships between the structural components of a defined series of PEO-PPO-PEO block copolymers and i) their interactions with biological membranes; ii) their cytotoxic potential were probed using a combination of haemolysis studies and cytotoxicity assays in the Caco-2 and HMEC-1 cell lines. "
3.	Glioblastoma (Glioblastoma Multiforme) 04/01/2021 - "In this study, poly (ethylene oxide)/poly (propylene oxide)/poly (ethylene oxide) (PEO-PPO-PEO, Pluronic F127) and poly (dl-lactide-co-glycolide-b-ethylene glycol-b-dl-lactide-co-glycolide) (PLGA-PEG-PLGA), the two most common thermosensitive copolymers, were utilized as local delivery systems for salinomycin in the treatment of glioblastoma. "
4.	Breast Neoplasms (Breast Cancer) 08/01/2010 - "Effect of poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) micelles on pharmacokinetics and intestinal toxicity of irinotecan hydrochloride: potential involvement of breast cancer resistance protein (ABCG2)." 11/01/2012 - "In this work, we developed PEO-PPO-PEO micelles loaded with irinotecan hydrochloride (CPT-11) using breast cancer resistance protein (BCRP) inhibitory material PEO20-PPO70-PEO20, and studied its mechanism of decreasing CPT-11 induced delayed diarrhea and intestinal toxicity. "
5.	Stress Fractures (Stress Fracture) 01/01/2020 - "These comprehensive analyses of the entire osteochondral unit with multiple standardized evaluation methods indicate that rAAV-FLAG-hsox9/PEO-PPO-PEO hydrogel-augmented microfracture significantly improves cartilage repair with a collagen fiber orientation more similar to the normal cartilage and protects the subchondral bone plate from early bone loss."

Related Drugs and Biologics

1.	kaempferol
2.	Ethylene Glycol (Monoethylene Glycol)
3.	dilactide
4.	poly(lactide) (polylactic acid)
5.	salinomycin
6.	polyethylene glycol-poly(lactide-co-glycolide)
7.	Poloxamer (Poloxamer 407)
8.	Micelles
9.	Irinotecan (Camptosar)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics
2.	Bone Plates (Bone Plate)