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rho guanine nucleotide exchange factors (rhoGEF)

Subscribe to New Research on rho guanine nucleotide exchange factors

guanine nucleotide exchange factors for rho gtp-binding proteins

Also Known As:

rhoGEF; ARHGEF1; ARHGEF1 protein, human; ARHGEF3 protein, human; ARHGEF4 protein, human; ARHGEF6 protein, human; ARHGEF7 protein, human; Arhgef6 protein, mouse; Arhgef7 protein, mouse; Arhgef7 protein, rat; Asef protein, human; COOL-1 protein, human; Cool2 protein, human; MRX46 protein, human; P115-RHOGEF protein, human; PAK-interacting exchange factor beta; PAK-interacting exchange factor beta protein, rat; PIX protein, human; PIX protein, rat; Rac-Cdc42 guanine nucleotide exchange factor (GEF) 6, human; Rac-Cdc42 guanine nucleotide exchange factor (GEF) 6, mouse; Rho guanine nucleotide exchange factor (GEF) 1; Rho guanine nucleotide exchange factor (GEF) 1 protein, human; Rho guanine nucleotide exchange factor (GEF) 3, human; Rho guanine nucleotide exchange factor (GEF) 4 protein, human; Rho guanine nucleotide exchange factor (GEF) 7, human; Rho guanine nucleotide exchange factor (GEF7) protein, mouse; Rho guanine nucleotide exchange factor 6; Rho guanine nucleotide exchange factor 6, mouse; Rho guanine nucleotide exchange factor 7; Rho guanine nucleotide exchange factor 7 protein, rat; XPLN protein, human; alpha-PIX protein, human; arhgef6 protein, rat; beta PIX protein; beta-Pix protein, human; betaPIX protein; betaPix protein, mouse; cool-1 protein; p115 rhoGEF; p115RhoGEF; p85Cool1 protein, mouse; rac-cdc42 guanine nucleotide exchange factor 6, rat; rho guanine nucleotide exchange factor p115

Networked: 97 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Intracellular Signaling Peptides and Proteins: 22
    - GTP-Binding Protein Regulators
      - Guanine Nucleotide Exchange Factors: 309
        rho guanine nucleotide exchange factors: 97
  - GTP-Binding Protein Regulators
    - Guanine Nucleotide Exchange Factors: 309
      - rho guanine nucleotide exchange factors: 97
- Peptides: 22950
  - Intracellular Signaling Peptides and Proteins: 22
    - GTP-Binding Protein Regulators
      - Guanine Nucleotide Exchange Factors: 309
        rho guanine nucleotide exchange factors: 97

Experts

1.	Kozasa, Tohru: 10 articles (09/2014 - 01/2003)
2.	Suzuki, Nobuchika: 7 articles (01/2016 - 01/2003)
3.	Webb, R Clinton: 7 articles (04/2010 - 10/2004)
4.	Ying, Zhekang: 6 articles (04/2010 - 10/2004)
5.	Gutkind, J Silvio: 5 articles (11/2013 - 09/2002)
6.	Tesmer, John J G: 4 articles (11/2007 - 10/2003)
7.	Kreutz, Barry: 4 articles (08/2007 - 01/2004)
8.	Grabocka, Elda: 3 articles (01/2016 - 10/2007)
9.	Wedegaertner, Philip B: 3 articles (01/2016 - 10/2007)
10.	Sternweis, Paul C: 3 articles (12/2015 - 07/2004)

Related Diseases

1.	Leukemia 01/21/2003 - "In this study, we analyzed the interaction of leukemia-associated RhoGEF (LARG), which also contains RGS domain, with Galpha12 and Galpha13. " 01/01/2016 - "Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1." 09/01/2013 - "Here we show that leukemia-associated RhoGEF (LARG), a RhoA-specific RGS-RhoGEF, is required for abscission, the final stage of cytokinesis, in which the intercellular membrane is cleaved between daughter cells. " 09/01/2013 - "Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission." 01/01/2013 - "To comprehensively examine Gα12 for regions involved in RhoGEF interaction, we screened a panel of Gα12 cassette substitution mutants for binding to leukemia-associated RhoGEF (LARG) and for activation of serum response element mediated transcription. "
2.	Hypertension (High Blood Pressure) 11/01/2013 - "RhoGEF-mediated vasoconstriction in hypertension." 06/01/2010 - "[The exchange factor Arhgef1: a new target in hypertension]." 09/01/2005 - "Because BS/GS represent the mirror image of derangements involved in hypertension, the reduced RhoGEF expression in BS/GS underlines a major impact of RhoA/ROK pathway on blood pressure regulation and confirms BS/GS as a good human model for exploring mechanisms involved in the pathophysiology of hypertension and remodeling." 01/01/2012 - "Studies to explore angiotensin II (Ang II) and its downstream signaling pathways via Rho guanine nucleotide exchange factors (RhoGEFs) and RhoA signaling are crucial to understanding the mechanisms of smooth muscle contraction leading to hypertension. " 08/01/2007 - "This is the first study demonstrating enhanced PDZ-RhoGEF/RhoA/Rho kinase signaling during hypertension at the level of resistance-sized arteries. "
3.	Breast Neoplasms (Breast Cancer) 10/01/2013 - "PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA." 10/01/2013 - "Furthermore, immunohistochemical analysis of human breast tumor tissues shows a significant increase of PRG expression in the invasive areas of the tumors, suggesting that this RhoGEF is associated with breast tumor invasion in vivo." 04/30/2015 - "We found that NGF treatment induced CD44 binding to TrkA at the plasma membrane and subsequent activation of the p115RhoGEF/RhoA/ROCK1 pathway to stimulate breast cancer cell invasion. " 09/30/2014 - "Obscurins are RhoGEF-containing proteins whose downregulation has been implicated in the development and progression of breast cancer. " 08/08/2003 - "Taken together, these findings strongly suggest that CD44 interaction with p115RhoGEF and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3-kinase membrane localization, AKT signaling, and cytokine (M-CSF) production during HA-mediated breast cancer progression."
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 05/19/2006 - "In this study we have examined the interaction of CD44 (a major hyaluronan (HA) receptor) with a RhoA-specific guanine nucleotide exchange factor (leukemia-associated RhoGEF (LARG)) in human head and neck squamous carcinoma cells (HNSCC-HSC-3 cell line). " 05/19/2006 - "Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells."
5.	Neoplasms (Cancer) 01/01/2015 - "RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1." 12/01/2014 - "The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. " 03/01/2011 - "The methylation level of oncogenes (ARHGEF1, RGF5), tumor-suppressors (APC2, BRACA2, DCC, GRLF1, RB1, TP73, TSPYL2, VHL) as well as genes, participating in chromosome segregation regulation (CNTROB, GMNN, PROCR, TACC1), was changed most frequently." 06/15/2006 - "To the authors' knowledge, this is the first epidemiological study to link PDZ-RhoGEF polymorphisms with cancer risk. " 05/01/2005 - "A recent report in Cancer Cell (Fernandez-Zapico et al, Cancer Cell 2005, 7:39-49) reveals an unexpected role for the hematopoietic-specific RhoGEF VAV1 in pancreatic tumorigenesis, where ectopic expression of VAV1 as a result of promoter demethylation was identified in the majority of established cell lines and PDA tissue samples. "

Related Drugs and Biologics

1.	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)
2.	rho-Associated Kinases
3.	Hyaluronic Acid (Hyaluronan)
4.	Angiotensin II
5.	rho guanine nucleotide exchange factors (rhoGEF)
6.	GTP-Binding Proteins (G-Protein)
7.	Proteins (Proteins, Gene)
8.	GTP Phosphohydrolases (GTPases)
9.	Messenger RNA (mRNA)
10.	Guanine

Related Therapies and Procedures

1.	Therapeutics