HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

sodium-dependent vitamin C transporter 2

Subscribe to New Research on sodium-dependent vitamin C transporter 2

a ubiquitously expressed nucleobase transporter-like protein from mammals; YSPL2 & YSPL3 are 60% similar; 650 amino acid residues; amino acid sequence in both sources; GenBank AF092511and AF058319 (human YSPL2)

Also Known As:

SLC23A1 protein; SLC23A1 protein, human; SVCT 2, ascorbic acid transporter; SVCT-2; SVCT2; SVCT2 protein, human; SVCT2 protein, mouse; Slc23a1 protein, mouse; YSPL2 protein; YSPL2 protein, human; sodium-dependent vitamin C transporter 2, human; solute carrier family 23 (nucleobase transporters), member 1; yolk sac permease-like 2 protein

Networked: 34 relevant articles (0 outcomes, 9 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fulzele, Sadanand: 3 articles (03/2014 - 12/2013)
2.	Chutkan, Norman: 3 articles (03/2014 - 12/2013)
3.	Sangani, Rajnikumar: 3 articles (03/2014 - 12/2013)
4.	Iguchi, Takuma: 3 articles (09/2012 - 10/2007)
5.	Wu, Ximei: 3 articles (09/2012 - 10/2007)
6.	May, James M: 3 articles (01/2012 - 09/2010)
7.	Tveden-Nyborg, Pernille: 2 articles (09/2014 - 05/2014)
8.	Lykkesfeldt, Jens: 2 articles (09/2014 - 05/2014)
9.	Hamrick, Mark: 2 articles (03/2014 - 12/2013)
10.	Isales, Carlos: 2 articles (03/2014 - 12/2013)

Related Diseases

1.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/01/2011 - "Thus, we studied the expression of SVCT2 after middle cerebral artery occlusion (MCAO) in mice by immunohistochemistry. " 08/01/2003 - "In the present study, we examined the response of SVCT2 mRNA expression in the brain to focal ischemia induced for 2 h by unilateral middle cerebral artery occlusion. " 08/01/2003 - "Effect of middle cerebral artery occlusion on mRNA expression for the sodium-coupled vitamin C transporter SVCT2 in rat brain."
2.	Neoplasms (Cancer) 10/01/2013 - "The expression of SVCT2 in cancers has so far received little study; but the extracellular acidity characteristic of many tumors would be expected to reduce the activity of this transporter, which has a mildly alkaline pH optimum. " 03/21/2013 - "Surprisingly, tumor regression by L-ascorbate administration in mice bearing tumor cell xenograft also corresponded to the SVCT-2 protein level. " 03/21/2013 - "Interestingly, SVCT-2 expression was absent or weak in normal tissues, but strongly detected in tumor samples obtained from breast cancer patients. " 10/01/2013 - "Unfortunately, since SVCT2 has a high affinity for ascorbate, and its activity is nearly saturated at normal healthy serum levels of this vitamin, increased oral administration of ascorbate would be unlikely to have much impact on the intracellular ascorbate content of tumors. " 10/01/2013 - "Expression and/or activity of the SVCT2 ascorbate transporter may be decreased in many aggressive cancers, suggesting potential utility for sodium bicarbonate and dehydroascorbic acid in cancer therapy."
3.	Ischemia 01/01/2011 - "Taken together, these results provide evidence for the expression and transport activity of SVCT2 in brain capillary endothelial cells after transient ischemia in mice. " 08/01/2003 - "In addition, the increase of SVCT2 in astrocytes after ischemia suggests that cultured astrocytes are exposed to chronic oxidative stress." 08/01/2003 - "In the present study, we examined the response of SVCT2 mRNA expression in the brain to focal ischemia induced for 2 h by unilateral middle cerebral artery occlusion. " 01/01/2011 - "Sodium-dependent vitamin C transporter 2 (SVCT2) expression and activity in brain capillary endothelial cells after transient ischemia in mice." 08/01/2003 - "The mRNA expression patterns of SVCT2 and the glutamate-activated immediate early gene Arc were investigated at 2 and 22 h after ischemia. "
4.	Glioma (Gliomas) 12/01/2013 - "Although glioma cells expressed high levels of the SVCT isoform-2 (SVCT2), low functional activity, intracellular localization and the expression of the dominant-negative isoform (dnSVCT2) were observed. " 12/01/2009 - "Ascorbate-decorated pharmaceutical nanocarriers were endowed with selective targeting properties toward the SVCT2 transporter expressed in glioma cell models. " 12/01/2009 - "Cell lines had been selected on the basis of the immunological properties assessed by FACS, which showed that two glioma cell lines, C6 and F98, and fibroblasts NIH/3T3 express plasma membrane-associated SVCT2 transporter for reduced ascorbic acid. " 12/01/2013 - "This study strongly suggests that the Bystander effect, that is, glioma cell interaction with oxidant-producing microglia, could be an important mechanism for glioma vitamin C loading in the absence of functional sodium-vitamin C cotransporter 2 (SVCT2) expression. "
5.	Choroid Plexus Papilloma 11/01/2013 - "In this study, the contribution of SVCT2 and GLUT1 to vitamin C uptake in human choroid plexus papilloma (HCPP) cells in culture was examined. " 11/01/2013 - "In choroid plexus papilloma cells, the vitamin C transporters SVCT2 and GLUT1 are polarized to the basolateral epithelial membrane, where SVCT2 is essential for AA flux from the blood vessels into the brain. " 11/01/2013 - "Thus, vitamin C can be incorporated by epithelial choroid plexus papilloma cells using the basolateral polarization of SVCT2 and GLUT1. "

Related Drugs and Biologics

1.	Ascorbic Acid (Vitamin C)
2.	Sodium
3.	Messenger RNA (mRNA)
4.	Vitamins
5.	Streptozocin (Streptozotocin)
6.	Apolipoproteins
7.	sodium-dependent vitamin C transporter 2
8.	Glutamic Acid (Glutamate)
9.	Complementary DNA (cDNA)
10.	Sodium Bicarbonate (Baking Soda)

Related Therapies and Procedures

1.	Cell Transplantation
2.	Heterologous Transplantation (Xenotransplantation)
3.	Tissue Therapy (Cell Therapy)
4.	Ligation
5.	Oral Administration