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SPA S 843

Also Known As:

N-dimethylaminoacetylpartricin A 2-dimethylaminoethylamide diascorbate; SPA S-843; SPA-S-843; SPK-843; SPK843

Networked: 3 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkenes: 265
      - Polyenes: 164
        SPA S 843: 3

Experts

1.	Izumikawa, Koichi: 2 articles (05/2008 - 05/2008)
2.	Kakeya, Hiroshi: 2 articles (05/2008 - 05/2008)
3.	Kobayashi, Tsutomu: 2 articles (05/2008 - 05/2008)
4.	Kohno, Shigeru: 2 articles (05/2008 - 05/2008)
5.	Miyazaki, Yoshitsugu: 2 articles (05/2008 - 05/2008)
6.	Seki, Masafumi: 2 articles (05/2008 - 05/2008)
7.	Senda, Hisato: 2 articles (05/2008 - 05/2008)
8.	Tashiro, Takayoshi: 2 articles (05/2008 - 05/2008)
9.	Yamamoto, Yoshihiro: 2 articles (05/2008 - 05/2008)
10.	Yanagihara, Kazunori: 2 articles (05/2008 - 05/2008)

Related Diseases

1.	Pulmonary Aspergillosis 05/01/2008 - "SPK-843, a new polyene antifungal, exhibited dose-dependent efficacy on murine pulmonary aspergillosis models. " 05/01/2008 - "Efficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspergillosis."
2.	Cryptococcosis 05/01/2008 - "Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis."
3.	Mycoses (Diseases, Fungus) 08/01/2005 - "SPK-843 is a water-soluble antibiotic under co-development by Aparts and Kaken for the potential treatment of systemic fungal infections. "
4.	Infections 05/01/2008 - "SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. "
5.	Body Weight (Weight, Body) 05/01/2008 - "SPK-843 doses of higher than 1.0 mg/kg of body weight exhibited no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone) (1.0 mg/kg) and liposomal amphotericin B (AmBisome) (8.0 mg/kg)."

Related Drugs and Biologics

1.	Amphotericin B (Amphotericin)
2.	Micafungin (FK463)
3.	liposomal amphotericin B
4.	Anti-Bacterial Agents (Antibiotics)