Human herpesvirus 8 G protein-coupled receptor

Also Known As:

G protein-coupled receptor, Human herpesvirus 8; G protein-coupled receptor, Kaposi's sarcoma-associated virus; G protein-coupled receptors, Kaposi's sarcoma-associated virus; KSHV-GPCR; receptor, G protein-coupled (KSHV); viral G-protein-coupled receptor, Kaposi's sarcoma virus

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - G-Protein-Coupled Receptors: 4701
        Chemokine Receptors: 5375
        Human herpesvirus 8 G protein-coupled receptor: 10
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Chemokine Receptors: 5375
        Human herpesvirus 8 G protein-coupled receptor: 10

Experts

1.	Gutkind, J S: 2 articles (03/2001 - 09/2000)
2.	Mesri, E A: 2 articles (03/2001 - 09/2000)
3.	Montaner, S: 2 articles (03/2001 - 09/2000)
4.	Sodhi, A: 2 articles (03/2001 - 09/2000)
5.	Couty, Jean-Pierre: 1 article (06/2009)
6.	Gershengorn, Marvin C: 1 article (06/2009)
7.	Lupu-Meiri, Monica: 1 article (06/2009)
8.	Oron, Yoram: 1 article (06/2009)
9.	Burger, Jan A: 1 article (03/2005)
10.	Burger, Meike: 1 article (03/2005)

Related Diseases

1.	Kaposi Sarcoma (Kaposi's Sarcoma) 12/30/1998 - "If KSHV-GPCR signaling is involved in viral pathogenesis, then these chemokines may affect the course of Kaposi's sarcoma and primary effusion lymphoma." 10/15/1998 - "Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8, a virus that appears to be involved in the pathogenesis of Kaposi's sarcoma and primary effusion lymphomas, encodes a G protein-coupled receptor (KSHV-GPCR) that exhibits constitutive signaling. " 03/02/1998 - "Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8, which is consistently present in tissues of patients with Kaposi's sarcoma and primary effusion lymphomas, contains a gene that encodes a G protein-coupled receptor (KSHV-GPCR). " 03/17/2005 - "The Kaposi's sarcoma herpesvirus encodes a G-protein-coupled chemokine receptor termed KSHV-GPCR. " 09/07/2001 - "Kaposi's sarcoma-associated herpesvirus (KSHV; human herpesvirus 8) encodes a chemokine-like G protein-coupled receptor (KSHV-GPCR) that is implicated in the pathogenesis of Kaposi's sarcoma (KS). "
2.	Primary Effusion Lymphoma 12/30/1998 - "If KSHV-GPCR signaling is involved in viral pathogenesis, then these chemokines may affect the course of Kaposi's sarcoma and primary effusion lymphoma." 10/15/1998 - "Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8, a virus that appears to be involved in the pathogenesis of Kaposi's sarcoma and primary effusion lymphomas, encodes a G protein-coupled receptor (KSHV-GPCR) that exhibits constitutive signaling. " 03/02/1998 - "Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8, which is consistently present in tissues of patients with Kaposi's sarcoma and primary effusion lymphomas, contains a gene that encodes a G protein-coupled receptor (KSHV-GPCR). "
3.	Infections 10/15/1998 - "The results suggest that KSHV-GPCR originated from CXCR1 or CXCR2 and that activation of KSHV-GPCR by endogenous chemokines may affect the pathobiology of KSHV infection in humans." 12/30/1998 - "Here we show that viral monocyte inflammatory protein-II (vMIP-II), one of the KSHV-encoded CC chemokines, and stromal cell-derived factor 1alpha (SDF-1alpha), a human CXC chemokine that blocks infection by human immunodeficiency virus-type 1, inhibit KSHV-GPCR signaling also. "
4.	Carcinogenesis 11/05/1999 - "These processes are believed to be important in KSHV-GPCR-related oncogenesis. "
5.	Wounds and Injuries (Trauma) 06/01/2009 - "We show that basal signaling by KSHV-GPCR inhibits migration of endothelial cells in two systems, movement through porous filters and in vitro wound closure. "

Related Drugs and Biologics

1.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
2.	Chemokines
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Chemokine Receptors
5.	GTP-Binding Proteins (G-Protein)
6.	Chemokine CXCL12
7.	Intercellular Signaling Peptides and Proteins (Growth Factors)
8.	CXC Chemokines
9.	CC Chemokines
10.	Cytokines