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escin Ia

from seeds of Aralia elata; structure in first source

Also Known As:

escin-Ia

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Pentacyclic Triterpenes: 108
        Escin: 218
        escin Ia: 4
Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - Escin: 218
      - escin Ia: 4

Experts

1.	Gao, Huiyuan: 1 article (10/2019)
2.	Long, Liping: 1 article (10/2019)
3.	Sha, Luping: 1 article (10/2019)
4.	Song, Kairu: 1 article (10/2019)
5.	Wang, Da: 1 article (10/2019)
6.	Xiong, Xin: 1 article (10/2019)
7.	Yang, Yiren: 1 article (10/2019)
8.	Zhang, Xinxin: 1 article (10/2019)
9.	Dai, Yue: 1 article (04/2016)
10.	Tong, Bei: 1 article (04/2016)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2004 - "[Studies on the biotransformation of escin Ia by human intestinal bacteria and the anti-tumor activities of desacylescin I]." 02/01/2004 - "To study Biotransformation of escin Ia by the crude enzymes of human intestinal bacteria and Lactobacillus brevis, determine the structures of biotransformation products and assay the inhibitory effect of desacylescin I on the tumor cell growth. "
2.	Triple Negative Breast Neoplasms 04/26/2016 - "Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression."
3.	Venous Insufficiency 01/06/2012 - "Escin Ia and isoescin Ia have been traditionally used clinically as the chief active ingredients of escin, a major triterpene saponin isolated from horse chestnut (Aesculus hippocastanum) seeds for the treatment of chronic venous insufficiency, hemorrhoids, inflammation and edema. "
4.	Neoplasm Metastasis (Metastasis) 04/26/2016 - "In conclusion, escin Ia was the main active ingredient of SFAC for the anti-TNBC metastasis activity, and its action mechanisms involved inhibition of EMT process by down-regulating LOXL2 expression. " 04/26/2016 - "In TNBC xenograft mice, the metastasis and EMT of MDA-MB-231 cells were suppressed by escin Ia. " 04/26/2016 - "Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression."
5.	Inflammation (Inflammations) 01/06/2012 - "Escin Ia and isoescin Ia have been traditionally used clinically as the chief active ingredients of escin, a major triterpene saponin isolated from horse chestnut (Aesculus hippocastanum) seeds for the treatment of chronic venous insufficiency, hemorrhoids, inflammation and edema. "

Related Drugs and Biologics

1.	Enzymes
2.	Triterpenes
3.	Saponins
4.	Glycosides
5.	Escin
6.	Doxorubicin (Adriamycin)